Firehouse 51 is faced with a daunting challenge when an out-of-control blaze consumes a 15-story apartment complex, trapping victims on the top floors. Complicating the rapidly escalating situation, members soon discover that someone close to home may be one of the trapped victims.

The crossover continues on Chicago Med S04E02 When to Let Go (II) and Chicago P.D. S06E02 Endings (III).

Chief Boden becomes increasingly skeptical of Assistant Deputy Commissioner Gorsch's motives, while Severide gets wrapped up in a difficult situation following the rescue of a child from a car wreck. Trying to fit in with the rest of the firehouse, Foster is tasked with doling out some personal advice to Cruz.

Firehouse 51 is called in to battle a dangerous structure fire that places everyone in peril. Severide makes a big personal realization. Casey lends another helping hand to Naomi, the investigative reporter.

Stakes are high when a massive car pile-up on the freeway impacts someone dear to the firehouse family. Brett and Foster encounter a harrowing call while Kidd and Severide find their relationship being tested.

Lt. Casey struggles to get Chief Boden to sign off on an energetic new recruit. Against her better judgment, Foster extends an olive branch to her irritating new medic. Otis inspires Herrmann to seek new partners at Molly’s. Brett realizes life in Fowlerton will take some getting used to.

A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).

Kidd must prove herself at the National Firefighter Leadership Conference while the rest of Firehouse 51 is called to two eerily similar car wrecks. Mouch tries to keep everyone in the firehouse informed by starting a newsletter, but things quickly get out of hand. Cruz deals with a heartbreak.

Tension builds when a group of rabble-rousers attempt to lock down the firehouse. Brett is faced with a monumental decision. Cruz readies himself for a big day. Gallo and Ritter attempt to launch Firehouse 51 into the social media age.