Casey faces pressure to cover for a cop's son, who was responsible for a drunken-driving accident that left a teenager paralyzed. Meanwhile, Severide ignores his doctor's warnings that his neck injury may never heal if he doesn't seek treatment; and Mills must choose between working at the fire department full-time or helping his mom with her restaurant.

When the shooting of a young girl happens in their neighborhood, Cruz and his brother, Leon are forced to think about the gang they have tried to escape. The battle between Chief Boden and McLeod continues to escalate and Isabella convinces Mills to dress up for a fancy gala. Meanwhile, Lt. Casey is sad Dawson won't be coming by as much now that his parental duties are over, Shay is fed up with the firehouse and digs in deeper with Devon and Zoya's visa is expiring, prompting her to come up with an idea.

Chief Boden prepares to counterattack McLeod in a final effort to save the firehouse from closure and the romance between Dawson and Casey escalates. Leon is making progress in the gang murder investigation, but Cruz cannot stand being left in the dark by Voight, fearing for his brother's safety. Meanwhile, Severide and Katie bond to make up for lost time and Otis feels uncomfortable living with Severide and Shay after Devon's latest escapade.

Lt. Severide hits the top of the list as Det. Lindsay starts calling in suspects with the clearest motives to make the guy who kidnapped Katie disappear. Meanwhile, Jones is still having trouble fitting in as word of her disruptions reach the fire department’s headquarters. Elsewhere, Herrmann celebrates his twentieth anniversary with his wife, but no one supports his idea on the gift he intends to give.

Lt. Casey and Dawson volunteer to help at a charity run at Chicago Medical when a massive explosion sends Chicago into chaos. With one of their own missing in the blast, the firehouse is tested like never before.

The crossover continues on Chicago P.D. S01E12 8:30 PM (II)

An apartment fire connected to a case of rape and attempted murder resembles an unsolved case in New York, so Sgt. Benson of Special Victims Unit comes to Chicago to help Intelligence with the investigation.

The crossover continues on Chicago P.D. S02E20 The Number of Rats (II) and Law & Order: Special Victims Unit S16E20 Daydream Believer (III).

At Sgt. Voight's urging, a determined Lt. Casey agrees to go undercover in an effort to provide proof of Jack Nesbitt's shady dealings. Meanwhile, Otis and Severide continue to disagree about the integrity of Scott Rice, causing tensions to flare between members of truck and squad. Meanwhile, Herrmann helps out a fellow member of the firehouse.

Lt. Casey puts his life on the line and digs deeper into the shady dealings of Jack Nesbitt. Chief Boden must figure out how to create unity in a divided house, while Severide comes to question his own judgment. A dangerous warehouse blaze quickly gets out of control and threatens members of firehouse 51.

Casey is placed in a dangerous situation while working undercover to bring down a trafficking ring being run out of Nesbitt's club. The squad's high turnover rate results in an unwelcome surprise for Severide. Dawson recognizes that her life is about to change. A new candidate makes an unusual first impression. Residents band together to protest a drug den in their neighborhood.

Boden's job is on the line pending an internal investigation. Severide adjusts to Patterson, his new commanding officer. Dawson shakes things up at the work. Casey searches for important evidence in his investigation of Nesbitt. Herrmann tries to keep the peace with Molly's new neighbors.

Boden suspects his neighbor is setting him up; Severide, who's still on probation, receives a surprise visit from his father and also learns something about Patterson that could be a game changer. Romance blossoms at a fire department gala.

Dawson and Casey deal with legal matters in hopes of remaining Louie's legal guardians. Severide continues in his efforts for a bone marrow procedure to help Anna, but when things don't go as planned, he finds himself slipping back into old habits. Meanwhile, Brett opens up to Dawson and members of Firehouse 51 become competitive, much to the dismay of Chief Boden.

The crossover continues on Chicago P.D. S04E09 Don't Bury This Case (II).

Truck and squad are called to aid in a massive all-city response when an old, ill-equipped factory-turned live/work space quickly turns into a firestorm, trapping countless unsuspecting victims. The dire situation quickly turns personal when it is discovered that one of Chicago PD's own has a family member at the scene.

The crossover continues on Chicago P.D. S04E016 Emotional Proximity (II) and Chicago Justice S01E01 Fake (III).

While working to track down a bombing suspect, Voight and Antonio meet with Chief Boden, who unwillingly agrees to let Dawson and Brett go undercover. As the investigation continues, Boden, Casey and Severide lend their skilled expertise in the investigation. Elsewhere, Kidd and Zach's relationship hits a bump and Cruz has a hard time expressing his true feelings for Brett. Meanwhile, Herrmann and Connie are forced to come up with an alternative solution when two birthday parties are booked on the same day at the firehouse.

The crossover starts on Chicago Fire S05E016 Profiles (I).

A spate of robberies comes to light after a firehouse lockbox key goes missing; Sergeant Hank Voight suspects a firefighter may be involved, and with Boden's support, he recruits Cruz to go undercover to help sniff out any suspicious activity.

The crossover continues on Chicago P.D. S06E15 Good Men (II).

A rare but deadly bacteria takes its toll on numerous victims around the city, leaving Chicago’s finest first responders to work together alongside the CDC to resolve the dangerous situation. Following a fire at a local university that ties into the outbreak, Severide has suspicions that something bigger is happening.

The crossover continues on Chicago Med S05E04 Infection, Part II (II) and Chicago P.D. S07S04 Infection, Part III (III).

A series of teen opioid overdoses sees Severide partner with Sean Roman, but begins to suspect there’s more to the story than his old friend is telling him. Casey tries to be there for Brett as she considers her birth mother’s offer to meet.

The crossover continues on Chicago P.D. S07E15 Burden of Truth (II).