Stephen begins by talking about how he survived the writers strike. He brings his writers (including, strangely enough, Tiki Barber, Mikhail Baryshnikov and Kevin Bacon) onto the set and welcomes them back personally. He then interviews David Gracer about eating insects. Stephen then introduces a new segment, "Stephen Colbert's Fallback Position," where he investigates different jobs he may take if he loses his job as a pundit. He investigates becoming a astrophysicist with Neil deGrasse Tyson. Finally, he interviews Richard Thompson Ford about the Democrats, and how he thinks the "race card" is being played too often.

Stephen briefly mentions the arrest and indictment of Illinois Governor Rod Blagojevich. A discussion on Frost/Nixon, he interviews Kevin Bacon about the film. As a prelude to Thursday's new episode of Tek Jansen, Stephen shows the previous installment. Finally, he interviews Charlie Kaufman about his new film, Synecdoche, New York.