Canaan, a covert agent with the power of synesthesia (the ability to combine senses), arrives in China just in time to save her friend, the young photojournalist Maria Osawa, from a deadly attack by the terrorist organization known as Snake. But Canaan has tenuous ties to various Snake operatives, which places Maria in peril.

As Minorikawa realizes Maria has a connection to the mysterious assassin Canaan, they are attacked in downtown Shanghai by a mysterious old man and his young accomplice. But as they are on the run from the dangerous duo, Canaan comes to their rescue, provoking a dangerous revenge.

Rescued by her "sister" Liang-Chi, and now taking her place of power as the leader of the terrorist organization Snake, Alphard sets a trap for Canaan, luring her out into the open at a glamorous state dinner. Once there, Alphard reveals she and Canaan have more in common than Canaan ever let on.

As Alphard makes preparations for her attack on the global anti-terrorism conference, Liang-Chi devises plans of her own. Blackmailing Yun Yun with the threat of withholding medication she needs to survive, Liang-Chi coerces her into killing Canaan, using Maria as bait. Meanwhile, Minorikawa attempts to get closer to the mysterious Hakko, despite Santana's efforts to keep them apart.

When they enter the Factory's deepest chambers, Canaan, Maria, and the others find the diseased survivors of the horrible experiment. There, Hakko is confronted with her own horrible past, which gives Liang-Chi the advantage she needs to attack the group from within.