Against the initial resistance of the Group, Frank travels to Portland, Oregon, to investigate a murder at an animal shelter. He meets with Jim Horn, a profiler and candidate for the Millennium Group. But Horn is distracted by his imminent divorce, and there is tension between him and Frank. When the killer strikes again, Horn is losing control, and Frank not only has to catch the killer who leaves grisly messages on his victims, but he has to contend with Horn as well who is more than ready to stop the murderer with terminal prejudice.

Frank and Peter assist an FBI investigation when a mad bomber terrorizes Washington, D.C, by blowing up buildings then to come out looking like a hero, the bomber goes back into the wreckage to save victims. Frank and Peter help search for the bomber whose attention starved personality may be the key to his undoing.

Frank enters a hospital emergency room looking for Catherine, who is working the night shift in child counseling. Suddenly, paramedics rush in with a bloodied woman on a gurney. Frank is inexplicably drawn to the stranger, and as he moves closer, notices a curved slash on her palm. He raises his own right hand, revealing a thin white scar which matches exactly the slash on the victim's hand. The woman dies from her injuries.

After Catherine Black goes missing in the Seattle Airport in the previous episode, Frank Black desperately searches for his wife, who has been abducted by a cunning stalker who is luring him into a trap.

In rural Arkansas, Frank investigates the owner of a daycare center accused of child abuse, only to be accused himself.

On Halloween, Frank experiences eerie visions and strange events that spark flashbacks to his youth—and a telling encounter with a troubled World War II veteran.

Millennium Group offender profiler Frank Black investigates the abduction of a bus full of schoolchildren, requiring the help of fellow Group members Peter Watts and Lara Means as he tracks a man preparing for a third world war.

Frank and Watts travel to Germany where they seek a legendary Holy relic.

Asylum inmates become prime suspects in a series of murders linked to an urban legend.

The discovery of the remains of the Crucifixion Cross threatens to divide the Millennium Group.

As the schism between the two warring Millennium Group factions deepens, Frank discovers the existence of yet another player in the power struggle.

A mysterious Asian woman is linked to several strange deaths aboard a ship.

In Wisconsin, in 1986, a farmer discovers thousands of dead birds inside his chicken coup warehouse, pools of blood encircling each cage. The farmer races for a phone, but collapses on his hands and knees, black papules having grown over his lymph nodes.

In this continuation of the previous episode... Jordan, Frank and Catherine bury the dead parakeet, prompting more questions from Jordan regarding God and the hereafter. Later, a Millennium team clad in bioharzard suits sweeps into the Davis home, where earlier an entire family was wiped out by the mysterious virus. Outside the house, in the backyard, are a dozen dead birds of various species.