Dr. Mike faces the prospect of leaving her practice and friends for Wyoming when Sully is offered a job surveying Yellowstone National Park.

Kid Cole and Sister Ruth (Johnny Cash and June Carter Cash) visit Dr. Mike at a difficult time in their marriage.

Sully, depite being wounded by two bank robbers, works to free his wife, Brian and Katie when they are taken hostage by the desperate men.

Sully is wanted for treason and murder. In order to keep him safe, Michaela pretends that Sully is dead and has a memorial service for him. Hank and Jake find out Sully is alive. Cloud Dancing and Sully meet with Black Moon.

Marjorie brings a group of Temperance Women (opposed to alcohol consumption) to C.S. Jake goes on a dangerous drinking binge, when he thinks Hank and Teresa are seeing each other. Grace begins to drink heavily to numb her grief. Robert E. moves out.

Chinese immigrants set up camp. Dr. Quinn discovers a young woman (Yumi Iwami) posing as a man in order to practice medicine, which is forbidden in her culture. Her Grandfather (Robert Ito) is stunned, but supportive.

While away with Sully, Michaela falls and hits her head. She suffers a concussion. The pain of losing her baby is finally discussed and resolved with Sully's.