A gunslinger (Johnny Cash) arrives looking for a quiet town in which to hang 'em up, but Colorado Springs is itching to lynch an immigrant (Christopher Keene Kelly) for cattle rustling to feed his starving family.

Love finds visiting faith healer Sister Ruth, in the form of Kid Cole, who's revisiting the town in order to jail a desperado he's apprehended. The desperado's two brothers have followed him to town and stalk him. Kid Cole, strangely fatalistic, seems to have lost the will to live. Things come to a head when Mike and Sister Ruth must unite their mutual strengths; medicine and faith, to save Kid Cole's life. Mike performs an emergency procedure to evacuate the tubercular Kid Cole's lungs; Sister Ruth helps him find the will to live. Sully forces Kid Cole to reveal that Kid Cole feels terribly guilty for having gunned down the desperado's brother, who was unarmed. Sully helps the Kid resolve this crisis of conscience and in a climactic showdown, the town helps the Kid avert a gun battle with the desperados. Meanwhile, the Reverend refuses to allow Robert E and Grace to marry in the town church, but eventually capitulates to their demands, with some help from Mike and Sister Ruth.

Mike and Sully run into now-married Kid Cole and Sister Ruth and invite them home for Thanksgiving, but the coach is hijacked, forcing them to journey home, on foot, through Indian country. Also, the Cooper kids scramble to put Thanksgiving supper together. Kid Cole: Johnny Cash. Sister Ruth: June Carter Cash.

Kid Cole and Sister Ruth (Johnny Cash and June Carter Cash) visit Dr. Mike at a difficult time in their marriage.