Horror mounts when a flu epidemic attacks Colorado Springs. Dr. Mike must attend the sick townspeople and protect others from getting the deadly disease. But being a lady doctor has people questioning whether she can handle the fatal epidemic.

A bitter Loren, who blames Sully for his daughter's death, tries to repossess Dr. Mike's cabin when he learns he still owns the deed.

Dr. Mike tries to heal the soul of Doc Eli, a Civil War surgeon turned patent medicine show huckster, who's come to like the taste of his own medicine, an all-curing elixir used by the fabled Kickapoo Indians. She doesn't trust the sales pitch of this exploitave medicine show man, especially when she's facing a real medical crisis involving Myra. She must help Doc Eli face his past demons, before he can help her remove an ovarian cyst from Myra, in a technique he pioneered.

Meanwhile Sully's on a similar mission in trying to convince Franklin, a disillusioned Cheyenne, survivor of a massacre, to join his own people in their continuing fight for survival. Myra and Horace get engaged.