Shu Ouma is a 17 year old teen who has poor social skills who lives in Japan where it is under the strict rule of the government organization GHQ due to the Apocalypse Virus ten years ago. While going to his warehouse studio, he encounters Inori Yuzuriha, internet singer of the band Egoist, who is recovering from her wounds after stealing a formula called Void Genome from the GHQ. After mending her wounds and feeding her, Inori is captured by the GHQ Anti Bodies division led by Major Guin and Shu is powerless to stop them. To make amends, Shu brings the Void Genome to Inori's boss, Gai Tsutsugami, leader of the resistance group, the Undertakers at Roppongi. However, Major Guin orders the Anti Bodies to exterminate the residents of Roppongi in order to find the Void Genome. As the Undertakers and GHQ battle, Shu goes and rescue Inori and protects her when a GHQ Endlave mech tries to attack them. The attack breaks the test tube holding the Void Genome, giving Shu the "Power of Kings" where he pulls out Inori's Void, a large sword and destroys the Endlave.

After Mana is completely resurrected, Mana greets Shu but is shunned by him after she speaks ill of Inori, much to her anger. Gai draws out Mana's Void to fight Shu while she triggers the Fourth Apocalypse, spreading the Apocalypse virus throughout the entire world. Haruka confronts Shuichiro who commits suicide by injecting the virus into himself. Meanwhile the Undertakers fight a group of Endlaves led by Daryl, who believes he changed because of them and wants to go back to his old self. Tsugumi finds that her attempts to hack the GHQ system are being repelled by another hacker as skilled as her. Shibungi figures that the hacker is actually Kenji and after tracking his location, he kills him, allowing Tsugumi to operate freely and help Ayase defeat Daryl. Just when Shu is about to be killed by Gai, Shu is seeing a flower while hearing the Voice of Inori.