After Charlie’s hand moved in the last episode, Alex has high hopes for his recovery, while she treats a patient who already has multiple surgeries under his belt. Meanwhile, Charlie coaches a young man killed in a roofing accident who has unfinished business with his severely injured brother.

With Charlie's life hanging in the balance, Alex and Dawn go head-to-head over who gets to be his legal decision maker - but are forced to put personal matters aside when they scrub into a heart transplant surgery together. Charlie, meanwhile, is in no mood to talk to the heart donor - a deceased prisoner.

A last-resort operation is performed on Charlie, who must confront his past in order to awake from his coma. Elsewhere, Joel leads risky surgery on a female jockey, and Alex could potentially cross a line when working with an Alzheimer's patient.

Alex must learn to stick up for herself and not be intimidated by Dawn (Charlie’s ex-wife) in order to work alongside her and perform a minimally invasive heart procedure to save a patient’s life. Meanwhile, Joel unlocks a mystery to a young girl’s disease, while getting some advice from Charlie, who is trying to figure out how to help his comatose patient come back from being a spirit. It’s a week of defying the odds at Hope Zion Hospital.

When Alex is forced to put a patient’s gender reassignment surgery on hold, she discovers a secret in his medical history that could save his surgery, but tear his life apart. Charlie deals with a patient who is healthy, sane – and convinced she is going to die at midnight. Meanwhile, Joel secretly helps Sonja deal with a patient of hers who’s been admitted to Hope Zion Hospital.

Alex risks a dangerous surgery on a seemingly inoperable tumor to save a young boy’s life. Meanwhile, Joel struggles with the challenges of being Chief of Surgery as Charlie struggles with the spirit of Alex’s dead brother Luke.

An elderly patient believes she's living in a different time; Charlie and Joel get competitive; Maggie is forced to take the reins during a surgery.

Alex encounters a trapped teenager during a hike in the woods; a woman refuses to see anyone but Joel; an exotic dancer comes to the ER.

Alex and Dana try to save a single mother's life; a hockey player's mobility is at stake; Charlie gets advice on winning back Alex; Sydney come clean

On her first day back from maternity leave, Dr. Alex Reid has her hands full when a new mother comes in following a car accident.

When a trapeze artists dies, a line of patients in need of his organs cause complications.