After Charlie’s hand moved in the last episode, Alex has high hopes for his recovery, while she treats a patient who already has multiple surgeries under his belt. Meanwhile, Charlie coaches a young man killed in a roofing accident who has unfinished business with his severely injured brother.

A high profile double hand replantation becomes Alex's (Durance) chance to prove to Kinney (Wendy Crewson) that she is still capable of being Chief Surgical Resident. In the ICU, Maggie (Ross) believes a homeless man may have been misdiagnosed.

A routine surgical procedure goes awry when Alex's patient, a soon-to-be-wed young woman, falls into a coma. While Alex struggles with a case that hits close to home, Joel treats a patient who does his own body modifications, and Charlie finds himself drawn to Alex's coma patient in the spirit world.

Alex is trying to get her life back to normal with Charlie and at Hope Zion Hosital – but with Charlie’s head in the clouds and the pressure to find her medical niche – she’s struggling. Inspiration comes in the form of an immigrant doctor who needs Alex to save his wife’s life, and in return, helps her find her calling.

Alex is awake but still not back to her old self, and Dawn has given strict orders for her recovery plan. Meanwhile, Charlie and Joel square‐off over differing treatment options when two fused-together burn victims are brought into the ER, and Maggie finds herself in a whirlwind of emotions triggered from the fallout of her miscarriage.

Dr. Alex Reid puts her reputation on the line when she questions a senior surgeon’s methods.