When a severely injured man under the spell of hypnosis can't remember his identity, the hypnotist who put him under is called into the hospital - where he uses his psychic ability to connect Charlie and Alex.

Charlie’s ex-wife, Dawn, has pulled the plug on his ventilator. All that’s left now is to wait for his breathing to stop. Devastated, Alex vows to stay by Charlie’s side. Meanwhile, Charlie – resisting his death – bumps into Mack MacIlreath, a recently deceased colleague, who has come to help Charlie die. Alex decides to lawyer up and appeal to the Consent & Capacity Board. While the process gets started, Alex is pulled away to meet with a patient: a young woman named Bea, who Alex performed surgery on while working as a first year surgical resident under Dr. Charles Harris. Bea’s check-up is all clear, but Mack and Charlie fear that she was misdiagnosed. And if Alex doesn’t catch it before Bea walks out of the hospital, she could die. Elsewhere, Joel’s hand is broken and he cannot operate until it is fully healed. Stuck with doing consults, he takes the case of a choir singer who makes a “miraculous” recovery from her paralysis.

When a heat wave hits the city, Alex is appointed Trauma Team Leader as the hospital is faced with an influx of patients during a blackout. With no back-up power available, Dawn and Charlie must figure out a way to continue their surgery as Joel and Maggie attempt to keep a patient alive while stuck in an elevator.

A couple is attacked by a bear, but Alex and Charlie think there's more to the story; a Buddhist tries to teach Joel a lesson.

Alex and Joel are challenged with a marathon surgery. Charlie has a day off that's full of surprises. Dana, Zach and James are tested.

During an ice storm on Christmas Eve, Alex and Dawn fight to keep a woman alive long enough for her family to say goodbye.