Hiromu has difficulties in forming Go-BusterOh for the first time with Ryuji and Yoko, and Enter sends the SprayRoid in a plan to bring the damaged MegaBuster Gamma (formerly CutterBuster) back online to destroy the Go-Busters from the inside out.

A rookie mechanic takes over maintenance of the Go-Buster Ace, making Hiromu feel unsure if he is ready. The Denshaloid attacks, and there is a problem when preparing Ace to combat the new Vaglass Megazord...

Finding the Energy Management Center base's air conditioner on the fritz, Hiromu and Yoko find Ryuji overheating before he loses consciousness. After the others get him to the medical ward, having met Masato earlier, Gorisaki frets when told by the man that Ryuji's inclusive medical checkup says he might die the next time he goes berserk. Hiromu and Yoko come up with a plan to save Ryuji before they are deployed to the Nakaya district where they face off against Dumbelloid before they find themselves exercising against their will, allowing the Metaloid to escape. Soon after, after playing the age card, Hiromu convinces Kuroki to make Morishita the new Blue Buster, much to Ryuji's dismay.

When a prank call brings the Go-Busters and Enter and his new Metaloid Keyloid to a hotel, they all meet Messiah's newest avatar in the real world: Escape.

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The Go-Busters and Gavan work together to stop Rhino Doubler.

Yoko gets invited to the wedding of her elementary school teacher Mr. Hasegawa, but when Tiaraloid begins to steal happy newlywed couple's data, causing them to go insane, Yoko is put in the place of Mr. Hasegawa's wife as bait for the Messiah Metaloid. However, the Go-Busters find themselves facing an upgraded Escape as well.

Hiromu learns of an MMA match, but when Enetron begins to be siphoned off at alarming rates the Go-Busters investigate to find four enemy Megazords have arrived in reality, forcing Red Buster to participate in a Megazord Deathmatch.

While celebrating the New Year, Hiromu discovers that his sister is going out on a date with someone, and he tries to see who it is all while a presumed dead Vaglass member enacts his revenge.

Yoko and Ryuji get into a fight after she asks him for advice and he brushes her off. However, when Enter sends a recreated Escape to attack, Ryuji is pushed over the edge of his Weakpoint with everyone placed in severe danger.

With Enter's new ability to convert living creatures into Metaloids, the Go-Busters work hard on trying to get Hiromu to overcome his chicken-themed Weakpoint.