Dr Sam Stewart runs a remote medical clinic on Hope Island in the Great Barrier Reef. She’s a GP, but in her spare time she and her colleague, Gus, chase the venomous creatures that inhabit the area.

Sam and Gus go on a monitor lizard hunt while the new doctor, Rick, has trouble adjusting to working in a remote clinic. Meanwhile, a new bride on her honeymoon steps on a deadly stonefish.

To pay for a much needed outboard motor, Sam gives a lecture to Andrew’s medical students at the Mainland University. Whilst there, she discovers her rival Malcolm has a newly renovated hi-tech lab.

On Freya's day off, Sam and Gus take her on a venomous spider hunt. When Gus falls into a stinging bush and Sonny loses consciousness out on the reef, Freya experiences a real test in emergency medicine.

It's a busy monthly clinic day on Hope Island and Rick is keen to see some new patients. Sam and Livvy try to get him to improve his bedside manner and listen to their complaints.

Andrew tells Sam that her clinic may be in line for an upgrade but when she heads to the university to discuss the details, she discovers he means to give her research to an independent research foundation.

Toby runs into trouble with sharks while diving alone, in secret. Meanwhile, romance is in the air as Gus asks Livvy out and Rick and Freya discover their mutual attraction.