Mob Wives Chicago is an American reality television series on VH1 that premiered on June 10, 2012, and is a spin-off of VH1's New York-based Mob Wives, with a new cast based in Chicago, Illinois. The introduction for the show was filmed on March 7, 2012, behind Chicago's Cassidy Tire on Canal Street. The first promo for the show aired on April 29, 2012, during a new episode of the original series. A preview special of the new series aired on May 27, 2012, after the second part of the Mob Wives reunion special.

On October 14, 2012, cast mate Pia Rizza tweeted, "#MobWivesChicago is over now I don't see the need to keep reliving the drama that killed the show time 2 move forward new chapter new time". She confirmed that Mob Wives Chicago has been canceled.