The Lone Gunmen reveal the (possibly fake) secret history of the Cigarette Smoking Man to Mulder and Scully; from a young captain in the U.S. Army recruited to assassinate President Kennedy, to becoming the mysterious man in the shadows at the height of a global conspiracy.

When Mulder and Scully try to discover what unseen force may have driven a scientist to commit suicide, they turn up a laboratory where extreme genetic experimentation has bred subjects possessing dangerous powers.

While investigating human organ theft, Mulder and Scully uncover a mysterious cult consumed with macabre rituals.