Agent Luke Alvez (Adam Rodriguez) joins the BAU team, which is tasked with capturing a killer who escaped prison with 13 other convicts at the end of last season.

When JJ arrives home shaken after a rough case, she breaks down and tells her husband about the abduction of two children.

The BAU welcomes back Emily Prentiss as they are called upon to investigate the disappearance of three women

The BAU team searches for a serial killer along the Appalachian Trail in rural Virginia.

The BAU investigates if bullying may be the link between two high school students who are the sole survivors after both of their families are killed.

The BAU investigates when several young men and women are victims of disfiguring acid attacks. Also, Dr. Reid begins to settle into his new surroundings.

BAU-teamet blir bedt om å dra til Oklahoma for å etterforske en morderisk klovn som terroriserer den søvnige byen Guymon.

Teamet reiser til Chicago for å etterforske en mistenkt som etterlater røde roser på hvert offer. Ellers får Rossi et uventet besøk fra sin ekskone.

BAU-teamet blir tilkalt for å etterforske en rekke drap i Virginia, som det mistenkes skyldes bio-terrorisme. Garcia besøker stebroren sin for å ta seg av et familieanliggende.

En tidligere VICAP-agent blir funnet innestengt på et lager. BAU etterforsker hans paniske påstander om en seriemorder som kalles "The Strangler", noe som resulterer i at de stiller spørsmål ved alt de kan.