The BAU unit travels to NYC to investigate a series of murders that appears to have been committed by a vigilante conducting revenge on former criminals who have been released by the justice system.

The BAU team continues to unravel the clues given to each of them by a psychopath in order to save his most recent victim. Gideon decides not to focus on the personal aspects of the case. Rather, he tells the team to profile the killer as they would in any other investigation. Reid stays behind to work on a personal connection that could solve the case as one member of the team fights for life.

The daughter of high-powered diplomats, Special Agent Emily Prentiss joins the team, and she must convince Gideon and Hotchner she deserves the job based on merit and not on her family connections. The BAU is then called to St. Louis to investigate two serial killers who appear to be competing with each other. By setting a trap based on one killer's profile, the team creates a media event by which to capture the second killer.

The BAU is called to investigate after a wealthy couple is murdered in their home following a Super Bowl party.

The team investigates a serial killer who is targeting women at a small college in Flagstaff, Arizona. The BAU shuts down the campus, creates a detailed profile of the unsub, and arrests a suspect. However, the team members begin to have doubts about themselves when another woman is killed while the suspect is in custody.