As Mackenzie begins the transition into the office of President, she has to select a Vice President, a situation in which Nathan Templeton tries using to his advantage. Mackenzie's daughter, Rebecca, faces a crisis when her diary goes missing, which contains information about her mother that could hurt her.

Faced with her first national crisis - the death of nine DEA agents in Latin America - Mackenzie shows strength and resolve in dealing with a corrupt leader. Meanwhile, Nathan Templeton is approached by an ambitious congressman who served with Mac's Vice Presidential candidate, Warren Keaton, and is eager to divulge potentially damaging info in an effort to derail his nomination. Mac's teenage twins resume public school, only this time it's complete with secret service detail and press spectacle, and while popular Horace welcomes the attention, shy Rebecca finds it overwhelming.

When a destructive hurricane hits Florida, Mac and Templeton fly to Florida to survey the damage. While there, Mac learns of an emergency situation with an oil tanker off the Florida coast which could have devastating consequences. Meanwhile, Rod is seriously considering an offer to become Commissioner of Baseball.

When a tell-all book is published about Mackenzie Allen that contains confidential information suspicions arise. Meanwhile, the confirmation hearings for Vice Presidential nominee Warren Keaton begin, but raise questions about his past.

Mac has more than Thanksgiving turkey on her plate. She juggles military base closures in her home town, a death penalty case the Supreme Court will not hear and a visit with Mom. Joining her team is a young and savvy media strategist/advisor.

Mac suffers a burst appendix while aboard Air Force One. Since there is no Vice President in place, Templeton becomes acting President since he is the Speaker of the House and next in line. Meanwhile, there is an air strike that is crippling travel on Memorial Day weekend and Templeton ends up overstepping his bounds and handles the situation the way he wants to.