As Mackenzie begins the transition into the office of President, she has to select a Vice President, a situation in which Nathan Templeton tries using to his advantage. Mackenzie's daughter, Rebecca, faces a crisis when her diary goes missing, which contains information about her mother that could hurt her.

Faced with her first national crisis - the death of nine DEA agents in Latin America - Mackenzie shows strength and resolve in dealing with a corrupt leader. Meanwhile, Nathan Templeton is approached by an ambitious congressman who served with Mac's Vice Presidential candidate, Warren Keaton, and is eager to divulge potentially damaging info in an effort to derail his nomination. Mac's teenage twins resume public school, only this time it's complete with secret service detail and press spectacle, and while popular Horace welcomes the attention, shy Rebecca finds it overwhelming.

When a tell-all book is published about Mackenzie Allen that contains confidential information suspicions arise. Meanwhile, the confirmation hearings for Vice Presidential nominee Warren Keaton begin, but raise questions about his past.

Mac has more than Thanksgiving turkey on her plate. She juggles military base closures in her home town, a death penalty case the Supreme Court will not hear and a visit with Mom. Joining her team is a young and savvy media strategist/advisor.

A submarine strikes a seamount just off North Korean waters and Mac must ask the Chinese for help. Meanwhile, Dickie's constant need for information has begun to irritate everyone. Meanwhile the first family deals with the question of reelection.

Mac decides to stand by her friend and Attorney General nominee, Carl Brantley, after he gets hammered in his confirmation hearings. A cargo plane which contains military weapons goes missing over Pakistan and it's up to Vice President Keaton to resolve the situation. Meanwhile, Rod tries to settle in the domestic life, but soon faces a crisis when Kate is nowhere to be found.

Mac wants her Attorney General to look into an urban situation in Maryland because it's where Gardner is from. Mac is also briefed on the situation of the missing surface-to-air missiles that went down in a military plane crash over Pakistan and has to make sure that the weapons do not end up in the hands of terrorists. Templeton is ralling support for the Templeton Act which focuses on domestic crime and Mac is threatening to use her veto power in the hopes for more law enforcement and education over the bill's calls for tougher sentencing. Dickie learns that Vince is planning a commitment ceremony with his partner and he warns him not to invite Mac because it might hurt her in the polls.