Perceived by the public as "menaces," Hulk and Spider-Man are the only ones left to save the planet from destruction when The Collector captures every last hero on earth.

Venom is on the prowl and has his sights set on big targets. Hulk must save the day...without smashing as his friends are possessed by Venom. How will the Hulks take on this menacing parasitic villain who's only goal is to destroy Spider-Man?

When the Leader blows Devil Dinosaur up into gigantic proportions and lets him loose on New York City, it's up to Spider-Man and the Agents of S.M.A.S.H. to stop him.

The Agents of S.M.A.S.H. and the Avengers must work together to free Hulk from the Supreme Intelligence and prevent the destruction of Earth.