As Poplar prepares for Christmas, the nuns leave for the Mother House to vote in a new mother superior and to help care for a group of Chinese orphans. Meanwhile, Trixie returns to Poplar refreshed and is shocked to discover that many mothers no longer want to give birth at home.

Nonnatus House welcomes two new nuns. Valerie deals with a shocking case that arrives unexpectedly, and the other midwives must handle a complicated multiple birth.

Lucille helps elderly hoarder Clarice Millgrove who is struggling to keep her independence; Sister Hilda and the team work hard to help a Ghanaian family with an undiagnosed illness; Violet puts herself forward in the upcoming elections.

Valerie helps a struggling mother accept her son's birth defect. The Turners oversee a measles vaccination trial at the clinic as the team prepare for the Whitsun bank holiday.

The team tries to unite an estranged mother and daughter who are both pregnant. Trixie's friend is devastated to discover she is pregnant.

Poplar welcomes a brand new cervical cancer-screening clinic to the Institute and Dr Turner, Shelagh and Trixie are pleased to be part of the exciting new venture.

Mother Mildred returns and helps a docker family tackle end-stage pneumoconiosis. Lucille cares for an unmarried teenage mother who wants to keep her baby.

Mother Mildred decides it’s time for Sister Frances to attend her first solo birth. Trixie consoles a patient who discovers she has gonorrhea.

Sister Hilda digs deep to give her terminally-ill patient her final wish whilst the Turners must prepare to say goodbye to May. Fred and Reggie are keeping secrets from each other.

Mother Mildred and the Nonnatus House team head to the Outer Hebrides in response to a nursing shortage.

Dr Turner and Nurse Crane must deal with an alarming outbreak of diphtheria. Fred finds an abandoned baby in a dustbin, and the team must help locate its mother.

Sister Julienne cares for a pregnant prostitute, while Dr Turner puzzles over a mysterious string of symptoms.

Lucille is seconded to St Cuthbert's when a ward sister is off sick, but a lift malfunction sees her spend the evening with mother-to- be Connie instead of her planned rendezvous with Cyril.

Sister Julienne volunteers to put up four trainee doctors at Nonnatus House while they undertake the practical aspect of their obstetrics diploma, hoping the exercise will remind the council how vital the home is to the community and help remove the threat of demolition.

Sister Frances is at a loss when she cares for diabetic and recovering cancer patient Albert Calthorpe whose fiercely independent wife Grace refuses to accept further help, despite caring for her husband, her elderly mother and her pregnant daughter.

At the Turners, Shelagh receives a phone call from the Hong Kong adoption agency, which has the alarming news that someone from May's past has arrived in the UK and wants to see the little girl.

Trixie helps a blind mother, Marion, care for her new baby, but trouble starts when Marion’s sister calls Social Services to intervene.

Sister Julienne decides it is time to take matters in hand when a letter arrives from the council saying that it will cut funding to Nonnatus House and no longer pay for the accommodation, and goes to see Violet at one of her open sessions as a local councillor.

The circus comes to Poplar, putting a magical spell on its residents. A delighted Shelagh is reacquainted with an old friend, and Trixie receives an unusual gift.

Sister Julienne and Dr Turner clash over whether to provide a private care service, and a distressing birth raises fears of another Thalidomide case.

Sister Frances finds herself in a tricky situation when a pregnant woman confides in her. Sister Julienne’s new venture hits a stumbling block.

Sister Hilda and Dr Turner are involved with a young woman whose health presents a series of challenges. A complicated pregnancy leads the Nonnatus team on a path of discovery.

It’s July 1966, and Britain is in the grip of World Cup fever. New pupil midwife Nancy makes quite an impact.

With sister Hilda away on a refresher course, sister Julienne steps in to carry out home visits. The new pupil midwives are settling in well, and there is a sense of hope in the air. 

While examining expectant mother Vera Sands during a routine visit, sister Julienne is concerned by her toddler daughter who is displaying troubling symptoms. Determined to find out what’s wrong, sister Julienne and doctor Turner are on the case. 

Meanwhile, an overly protective mother struggles to cope with her daughter’s teenage pregnancy and is insistent on keeping it low key, much to the frustration of new pupil midwife Nancy Corrigan. 

It’s September 1966, and at clinic Trixie is tasked with examining a desperate woman who is pregnant with her fifth child. Trixie learns that her patient’s personal life is far from stable, compelling her to speak out publicly. However, the results garner mixed reactions from Nonnatus House and the community.

Dr Turner and Sister Frances are entrusted to help a mother-to-be who refuses medical care through her final weeks of pregnancy, and Nancy Corrigan reveals a secret about her background that could threaten her relationship with Sister Julienne and Nonnatus House.

Nonnatus House struggles to come to terms with Nancy’s revelation. With Sister Julienne taking her annual leave at the Mother House, Sister Hilda relishes the chance to cover and impress with her leadership.

While attending an expectant mother, Sister Frances and Trixie are appalled to learn that Poplar’s housing crisis is worsening, leaving the Nonnatus team vowing to fight for change.

It’s a poignant time for the Turner family as Timothy readies to leave for medical school in Edinburgh and Cyril receives news from home, prompting him and Lucille to consider their own future.

Meanwhile, a very special baby is born, who causes a rift in a close-knit family and leads many people to count their blessings.

Christmas promises to be a memorable one at Nonnatus House as Lucille and Cyril prepare for their upcoming winter wedding. The Nonnatus team are faced with their busiest Christmas Day ever as the Maternity Home is filled with expectant mums-to-be, each with their own challenging case. Luckily Mother Mildred is on hand to support the team.

Demolition work in Poplar uncovers a long-buried secret that leads to a testing and emotional case for the team. Sister Julienne takes on a sensitive delivery.

At the monthly cytology clinic, Sister Frances comforts a young woman who is struggling with a life-changing diagnosis. Lucille supports a difficult mother.

Shelagh organises a special celebration to mark 100 years since the Order first arrived in Poplar - although Sister Hilda feels that she should have been in charge of the festivities. Nancy tackles the plight of meths drinkers living rough in Poplar, and Nurse Crane treats a young singer who is torn between two very different futures.

Sister Hilda and Dr Turner support a young father with a lung condition whose wife is planning a home birth, and discover he is also coping with the repercussions of a past trauma. Cyril looks for a job that will put his qualifications to good use, a first-time mother struggles to bond with her daughter, and Fred comes up with a way to keep the wards cool during a summer heatwave.

Trixie has been assigned to a complicated case involving a crane driver who was injured in a workplace accident and is now paraplegic. Meanwhile, Nancy and Sister Frances give a talk on the facts of life at a primary school, and Lucille's attendance at a straightforward delivery takes a distressing turn. Shelagh decides to organise a jumble sale to raise money to fix some broken playground equipment in the park. When Sister Julienne finds a suspicious item, chaos ensue

Sister Monica Joan seeks advice from a clairvoyant. Matthew is shocked to discover squatters in one of his warehouses, and Shelagh faces the most challenging delivery of her career.

Nonnatus House suffers its biggest threat yet. But this time it’s not the bricks and mortar that are in danger, it’s the people.

Nonnatus House faces its darkest day after a tragic incident in the heart of Poplar. As the community rallies together, the team must overcome personal anguish to help the injured.