Operating within the Defense Criminal Investigation Service of the U.S. Department of Defense and led by preeminent neurologist and psychiatrist Dr. Lee Rosen, an expert in Alpha phenomena, the team investigates cases that point to others with Alpha abilities. As they work against the clock to solve this new brand of crime, they must prevent their own personality differences and disparate backgrounds from interfering with their ultimate mission to catch the enemy.

While Bill and Gary take on a case of their own, Nina and Cameron grow closer.

The team is ordered to find and protect Skylar, an Alpha with skills that could be dangerous in the wrong hands.

An investigation leads Harken and Hicks to go undercover in a secret, underground Alphas-only Fight Club.

While the team tries to cope with Danielle's death, a mysterious woman drops a baby off at the office and Gary is strangely drawn to protecting it.

Rosen kidnaps and interrogates an Alpha prisoner; Harken and Gary search for Skylar.