Operating within the Defense Criminal Investigation Service of the U.S. Department of Defense and led by preeminent neurologist and psychiatrist Dr. Lee Rosen, an expert in Alpha phenomena, the team investigates cases that point to others with Alpha abilities. As they work against the clock to solve this new brand of crime, they must prevent their own personality differences and disparate backgrounds from interfering with their ultimate mission to catch the enemy.

The team moves to new offices following the attack on Rosen; violent riots break out on the east coast, which are linked to a runaway teen.

The Alpha team closes in on Red Flag and rescues an autistic woman, Anna, with the ability to translate any language. The team tries to figure out Red Flag’s plan while Gary bonds with Anna.

The team is ordered to find and protect Skylar, an Alpha with skills that could be dangerous in the wrong hands.

An investigation leads Harken and Hicks to go undercover in a secret, underground Alphas-only Fight Club.

Hicks and Kat transport a valuable Parish asset; Roland holds the strategic intel they need to stop Parish.

Rosen kidnaps and interrogates an Alpha prisoner; Harken and Gary search for Skylar.

Rosen seeks a final confrontation with Alpha leader Stanton Parish.