When the crew gets a flight taking journalists to Berlin to cover an important speech by President Kennedy, Maggie, who campaigned for him, is determined to meet JFK no matter what. Meanwhile, when her contact's safety is compromised, Kate tries to help the young woman escape East Germany; and painful memories of World War II force Colette to face her tragic past.

Sparks fly between Laura and a sailor on a special – and unusually wild -- Pan Am flight bringing servicemen home, leading Laura to realize what she’s really looking for in a man, as well as opening her eyes to the malicious racial climate in the country. Meanwhile Kate’s complicated mission to turn Niko to work for the U.S. government culminates in dramatic fashion, threatening their personal relationship.

Fate deals a blow to Dean and Colette's budding romance. Maggie writes a critical story for the Village Voice against her congressman's politics but doesn't count on falling for him after she submits it; though she wants to resist, the physical attraction between them is undeniable. Kate finds it hard to move beyond her last spy assignment and is haunted by the repercussions - she faces a fate similar to Bridget's if she cannot fake her way through a lie detector test. And Laura is in a tailspin as Ted thinks he's found the love of his life.

Dean is tapped to fly the first-ever commercial flight to Moscow, but the day of departure, a blowhard veteran pilot, Broyles, takes the controls and makes Dean co-pilot. While in Russia, Kate tries to pull off an important mission, but when Laura and another Pan Am stewardess are mistaken for spies, Kate tries to expedite their release with the help of an unlikely ally. Back at home, Congressman Rawlings and his staff work to track down whoever anonymously wrote the negative new story about him, and Maggie agrees to be his date at a fund-raiser. Can she keep her temper dealing with so many conservative political supporters and retain her cover as the article's author? Ted's relationship with Amanda gets serious, but Maggie learns something about her that may hinder this whirlwind romance.