Colette and Aaron have a long history of heroin addiction, which they've been able to kick with the aid of methadone. But now that Colette's pregnant, methadone carries risks both to her pregnancy and her unborn child. Colette's in a no-win situation, finding that it's possibly riskier to go off the methadone during pregnancy than to stay on it and deliver a baby who's also addicted.

Beth has always wanted children, but being pregnant isn't easy for someone with an eating disorder. Beth turns to her husband and therapy for help, but her urges to undereat and overexercise are constant, and if Beth gives in to them, she will put herself and her baby at risk.

Kathleen has it all-a job she loves, a loving 63-year-old husband, a sailboat for weekend getaways, a beach house, two devoted Portuguese water dogs. All except the one thing she always wanted-children. Now, at the age of 55, she's finally pregnant with her first child, a boy. But at her age, nothing about pregnancy is routine or easy.

Jolene and her boyfriend Correy are expecting a baby girl. But being pregnant has meant that Jolene had to choose between taking the psychiatric drugs that control her bipolar disorder and safeguarding the health of her unborn child. Now, without the medications, every day is a painful struggle.

When Sarah entered prison, she was three months pregnant. Since then, she has been struggling with being pregnant behind bars. Now, she is preparing for another challenge-after the baby is born, Sarah will bring him back to the prison, where he will live with her for the duration of her sentence.