Leo discovers three teen super-humans Adam, Bree and Chase, living in a secret underground lab in the high-tech home he shares with his inventor stepdad, Donald Davenport, his mom, Tasha, and Eddy, the "smart house" computer. Leo takes the trio to school, but when they are unable to contain their bionic abilities on campus, Davenport sends them away to a remote secret lab.

On the Lab Rats' first day of school, all goes awry when Chase is confronted by a football player and his "Commando App" is triggered, transforming him into Spike, an unruly drill sergeant. When Spike defies the school principal, she pits the Lab Rats up against the football team to battle it out for the coveted cafeteria table

When Adam, Bree and Chase forget to invite Leo to his surprise birthday party, they must make it up to him, so they take Leo into the ultra-cool virtual mission simulator and show him what it's like to be bionic.

Leo is left alone to care for the Lab Rats, but things quickly go wrong when he plays with a new gadget that glitches Adam, Bree, and Chase.

Adam, Bree and Chase learn about chores and earn allowance for the first time. To raise more money, they host a yard sale and accidentally sell an antique jewelry box that Davenport was restoring for Tasha.

Leo is blamed for breaking Marcus' guitar.

Chase accidentally discovers that he has a hidden ability - telekinesis.

Adam, Bree, and Chase sneak out to meet Marcus in Davenport’s new self-driving sports car. When Leo tries to stop them, his nemesis Marcus traps him inside the car and programs it to take him on a wild, high-speed ride bound for the bottom of the Pacific Ocean.

Leo finally goes a mission as he helps Davenport and Eddy attempt to stop an underground gas leak. Adam, Bree and Chase struggle to escape from Principal Perry’s detention lockdown.

When Chase is not pictured on the yearbook, he enters a talent show to show everyone he's popular by using his bionics to move a chair with his mind. But Leo messes with Chase's bionics and he was mad so he got revenge by going into commando app and then he messes with the kids in the school which causes Davenport to turn off his bionics until he learns his lesson.

Leo follows Marcus to his secret lair (an abandoned train station) to gather evidence that proves he's bionic but ends up captured by Marcus and told that there bionics are just some dumb tricks. Meanwhile, the Lab Rats scramble to bring Tasha back before Davenport finds out that they accidentally teleported her to parts unknown.

The truth behind Marcus and his father.

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In an effort to get out of training duties, Adam enlists Leo's help to create a duplicate Adam using Davenport's experimental cloning device. However, Adam's clone uses the same device to create another duplicate to avoid going to school and the clones he creates repeat the same process resulting in a mob of ever duplicating Adams.

The Lab Rats are forced to expose their bionic secret in order to save Principal Perry.

Since Principal Perry knows that the Lab Rats are bionic, she wants to get in the action and go on a mission with them. When they stage a fake mission and take her down to the newly built lab, things don't go as planned, and they have to save Mission Creek High from a speeding rocket. Meanwhile, Janelle goes on a date with Leo, but is beginning to see him as a jinx because she always gets hurt when he is around.

Bree is accepted for a semester abroad program in Australia, but when Donald learns about it, he refuses to let her go. When Donald again refuses to let her go to a concert with her friends in favor of bionic chip maintenance, she decides she's had enough and smashes her bionic chip, much to Adam, Chase, and Donald's horror. At first, Bree relishes her new freedom and even begins bragging to a disgruntled Leo. During a mission, Bree feels helpless as Adam and Chase are gone for hours. Chase reveals that they barely made it out alive and because Bree is no longer bionic, the mission took twice as long. Bree realizes she was selfish and apologizes to Adam and Chase. She's ready to become bionic again, but Donald sadly tells her that since Douglas built the chips, he isn't sure if Bree will ever be bionic again. Meanwhile, Tasha is sick, so Leo decides to use his new pill invention on her to see if her diagnosis will reveal the problem, but when he takes some of the software from Eddy, Eddy is stuck in Tasha's body. Eddy spends the day dressing her horribly and getting her kicked out of every spot in town. Donald finally uses his nasal vacuum on Eddy and the pill is extracted. However, Eddy reveals he did a news report as Tasha, and much to her shock, he made her look like a complete buffoon.

Donald gives Eddy a human body and replaces his disrespectful personality to make him nicer. Perry restores his old personality, and he attempts to harm the students.