While being pursued by the Enforcers, Spider-Man has to protect Norman Osborn from the vengeful supervillain Vulture.

When a lab accident transforms Max Dillon into supervillain Electro, he demands that Dr. Martha Connors find a cure as Spider-Man works to stop him.

Disguised as Spider-Man, the Chameleon embarks on a crime spree that can only be stopped by Spidey and the Black Cat -- together.

Both Liz Allan and Gwen like Peter. Whom should he pursue? Meanwhile, Kraven the Hunter has come to New York City to make Spider-Man his prey.

After alien spores infect John Jameson -- increasing his size, strength and mass -- his dad persuades him to become a superhero to capture Spider-Man.

Peter and his loved ones become vulnerable to all of Spider-Man's enemies when Venom exposes Peter's secret identity.

When the Green Goblin blackmails Liz's brother Mark into doing his bidding, neither Liz, Mary Jane nor Spider-Man may be able to save him.