A young prostitute's body is retrieved from Vancouver Harbour, and Sunny notes striking similarities to a string of previous deaths. A chance comment to Da Vinci leads him to re-open several cases, causing a further rift with his ex-wife Patricia, who did the original autopsies, and with his boss James Flynn, who ruled the deaths as accidental.

Following a rash of fatal drug overdoses, Da Vinci learns that one of the dead addicts had an infant, who is missing. Manny, a police informer leads Leary, with new partner Angela Kosmo, to the woman's drug dealers. They arrest Todd and Sioux, and through them Larry discovers that the killer heroin came from a French-Canadian supplier who, along with his partner, was murdered, gang-execution style, just days previously.

Patricia Da Vinci's career is on a high when she is asked to be a guest speaker at the prestigious Seattle Homicide Conference. Her presentation involves the recent case of the prostitute serial killer Charlie Josephs, who himself was found murdered. Her re-examination of the case leads to the discovery of several discrepancies and uncovers some new clues in Joseph's death, clues that seem to implicate the police.

Sioux, who is now a police informant for Kosmo, implicates Danny in the drug trade and Kosmo is forced to examine her feelings for him.

Da Vinci desperately searches for the truth behind a death in custody and implications of police corruption. The death of an elderly woman during a suspected home invasion puts rookie Coroner Winston at odds with the Chief Pathologist.

Da Vinci has to untangle the truth of two fatalities that happened during a controversial high-speed police car chase. Shannon and Leary try to solve that the hold up of an armoured car.

A fishing boat goes down in calm seas and three men with more than a century of experience die. Da Vinci, who is coping with his own grief, must navigate his way through the secrets of a grieving family, a stonewalling corporation and his own sympathies to find the truth.

The death of a child always hits hard for those who have to investigate, especially when it looks like suicide. Da Vinci tries to rein in a community on a quest to publicly expose a suspect.

Da Vinci and Shannon investigate a death that brings them face to face with their own ethics. Meanwhile, Leary takes on a dangerous undercover assignment.

When a baby dies from a brain injury, pathology turns up a lot of unanswered questions. Da Vinci is on the case. The police investigate a possible drug-related shooting.

The police catch a man with a sex-trade worker bound and gagged in his truck. Da Vinci questions whether this was a consensual act or the work of a man who has killed before.

Da Vinci ""tilts at windmills"" while investigating a death on the streets of his beloved downtown eastside. Shannon and Leary pursue an enigmatic double murder.

A death in custody is reported, but the prison warden says that no one's died. Da Vinci investigates. Shannon and Leary lead the homicide team in the search for a young boy who disappears after his mother is beaten to death.

Da Vinci investigates the death of a man left to die outside the emergency room. The whole homicide team is called in when an infant is abducted from her nursery.

Da Vinci leads the search for the body of a boy who fell into a river. Is there something more to the death than just a tragic accident? Kosmo investigates a man whose wife has disappeared. A doctor is shot on his way to a clinic. Shannon and Leary chase down his killer.

After a downtown Eastside activist is found dead, Da Vinci is approached by a witness who last saw the victim getting into a police cruiser. A woman is found dead in a dumpster with no signs of what killed her. Kosmo and Winston investigate.

Working with Shannon and Leary, Da Vinci investigates an apparent suicide in the woods of an ex-convict released on day parole. Patricia starts her new job as a professor at the university. Sunny finds some artifacts of interest in historic Chinatown. Detective Kosmo tries a new approach to an old unsolved case.

An eight year old's mysterious death leaves Da Vinci demanding answers. Shannon and Leary look into the double shooting of a stripper and a bouncer.

A detained Chinese boat migrant dies while on a hunger strike. Da Vinci investigates. Shannon and Leary's prime suspect is a possible stalker as they continue their investigation of a double homicide.

When a dead woman is found floating at sea in a small boat, Da Vinci is called in to investigate. Shannon and Leary probe the disappearance of a young pregnant woman.