Crews and Reese investigate a gas explosion in which an IRS agent leading a double life is the victim. Was it an accident or arson? Was the IRS agent trying to be a hero? Crews is once again a suspect in a murder investigation when the detective who handled his case is found dead.

Crews and Reese investigate the murder of a runaway girl found dead under a freeway overpass holding her guitar. A grocery store employee and his son become the prime suspects when they find out the girl used to play her guitar in front of the store. During the investigation they find ties to a kidnapping 12 years earlier. Are they connected?

Crews and Reese investigate the murder of a Zen Master who was buried alive ten years ago. Crews continues to investigate his own case. He finds some proof that his partner's father Jack Reese could be involved.

In the season two premiere, detectives Charlie Crews and Dani Reese are on the hunt for a serial killer when three numbered trunks containing suffocated bodies are found scattered across Los Angeles. With their new boss New York transfer Captain Kevin Tidwell pressuring them to get answers, Crews and Reese race to find a connection between the murders before the killer strikes again. Meanwhile, Ted and Crews attempt to track down the daughter, the lone survivor, of the family Crews was wrongly convicted of killing.

Charlie Crews and Dani Reese investigate the death of a family man who is found beaten and bound to a chair at the bottom of an empty pool. Captain Tidwell is convinced the murder was an act of gang violence and sends the detectives on assignment. After interviewing the victim’s daughters and two gang members, Crews and Reese’s only clues are an underground party circuit, a bottle of steroids, and a myth about a man only known as Monster. Meanwhile, Ted gets an unexpected visit from Dani’s father who is determined to find out what information Crews has on him and consequently has a request of Ted. Crews also enlists the help of his ex-wife Jennifer to reach out to Rachel , the lone survivor of the murdered family Crews was wrongly convicted of killing.

Crews and Reese are baffled when the body of a cancer research scientist is found frozen solid; Crews resolves to prove that Jack Reese was involved in his incarceration; Ted asks Crews to be a reference for a business school interview.

When a college student is found crushed to death in a wrecking yard, the probe leads Crews and Reese to a complex online love triangle; Crews continues his investigation into Jack Reese by hunting for the officers seen in his latest clue.