Tension in the Sorelli family arises when Anne finds out that her sisters are still keeping in close contact with her ex-boyfriend Danny. Bob becomes more concerned about Ginnie's prenantal health and the baby. Marjee is having difficulty on the new living arrangements of her boss' boyfriend. Lastly, Rose gets her first asting gig in a play written by and starring her crush, Alex (guest star Chris Carmack).

While Ginnie and Bob are told to refrain from having sex for a few weeks as a pregnancy precaution, Rose contemplates having sex for the first time as she finds herself really falling for Alex (guest star Chris Carmack). Meanwhile, Marjee and Jason (guest star Julian Ovenden), Marjee's boss’ boyfriend who Marjee recently madeout with, are put in charge of a huge wedding; and Anne winds up sleeping with Rose's classmate (guest star Andrew Keegan) after she spends an unbearable several hours with an awful wedding date (guest star Jonathan Silverman).

With a family Thanksgiving planned in Ginnie and Bob's loft, Ginnie, Anne, Marjee and cook a traditional Sorelli dinner using all of their mother Francesca's (guest star Dana Delaney in flashback scenes) favorite recipes. The sisters also reminisce about memories of their mother. Meanwhile, Anne is frustrated over her feelings for Rose's classmate, Zach (guest star Andrew Keegan, “7th Heaven”); and Renee (guest star Christine Ebersole, Tony Award winner for “42nd Street”) is rushed to the hospital with a stress-induced asthma attack after Ginnie blows up at her.

Returning from the Christmas break, Rose must face the two guys (guest stars Kyle Howard and Chris Carmack) in her life and decide which one is right for her. Marjee realizes she can't be the "other woman" any longer and gives Jason (guest star Julian Ovenden) an ultimatum, and Anne (Kiele Sanchez) fully embraces her fling with Rose's 19-year-old classmate, Zach (guest star Andrew Keegan). Meanwhile, Ginnie and Bob sit down with an attorney to draw up their wills, but quickly discover they have completely different ideas of who should be the guardian of their child in the event something should happen to them.