Ann continues her sad moodiness over her break up with Danny (guest star Dan Futterman) as she's staying home in her sweats and getting rid of old furniture---particularly her matress. She thinks it's cursed. Ginnie feels she needs to talk to Danny as she's still in a lot of pain over her relationship ending, but this causes some serious tension between the sisters. Marjee is having a hard time with her boss (guest star Anne Ramsey) as she's making her take the fall for a lot of the party planning mistakes that she didn't do as well as medicore chores on staff assistance. Marjee eventaully considers quitting

One of Rose's classmates, Zach befriends Ann despite their age difference. Flash (guest star Shanola Hampton) goes too far in one of her monologues in acting class when she mimics Rose's college life through a fake journey and makes fun of her. Rose then goes to the NYU Housing Office to find another room to get away from Flash, but is unsuccessful. Rose finds out Flash's real name---Tiffani Lusinski.

Tension in the Sorelli family arises when Anne finds out that her sisters are still keeping in close contact with her ex-boyfriend Danny. Bob becomes more concerned about Ginnie's prenantal health and the baby. Marjee is having difficulty on the new living arrangements of her boss' boyfriend. Lastly, Rose gets her first asting gig in a play written by and starring her crush, Alex (guest star Chris Carmack).

With a family Thanksgiving planned in Ginnie and Bob's loft, Ginnie, Anne, Marjee and cook a traditional Sorelli dinner using all of their mother Francesca's (guest star Dana Delaney in flashback scenes) favorite recipes. The sisters also reminisce about memories of their mother. Meanwhile, Anne is frustrated over her feelings for Rose's classmate, Zach (guest star Andrew Keegan, “7th Heaven”); and Renee (guest star Christine Ebersole, Tony Award winner for “42nd Street”) is rushed to the hospital with a stress-induced asthma attack after Ginnie blows up at her.

After forcing Bob to return the car he bought as a surprise for her, Ginnie has a change of heart and decides to have Marjee teach her to drive instead. Rose's new relationship with Alex (guest star Chris Carmack) hits a bumpy patch when he questions whether Rose's best friend, Joel (guest star Kyle Howard), has feelings for her; and Anne quickly realizes she may have bitten off more than she can chew when her father, Joe (guest star Tom Irwin), asks her to help his emotionally troubled fiancée, Renee (guest star Christine Ebersole). Rose questioneds her sisters about her realishonship with Alex

With Christmas festivities in full swing at the Sorelli house, Rose is torn between the two men (guest stars Chris Carmack and Kyle Howard) in her life, while Marjee finds herself in unfamiliar relationship territory when she realizes she may be developing feelings for her boss's boyfriend, Jason (guest star Julian Ovenden). Meanwhile, Ginnie is thrown for a loop when Bob announces at the last minute that his parents - most notably his cold-as-a-fish mother (guest star Judith Ivey) -- will be joining them for Christmas, and Anne is put in an awkward situation with her father, Joe (guest star Tom Irwin), and Renee (guest star Christine Ebersole), who is keeping a big secret.

Returning from the Christmas break, Rose must face the two guys (guest stars Kyle Howard and Chris Carmack) in her life and decide which one is right for her. Marjee realizes she can't be the "other woman" any longer and gives Jason (guest star Julian Ovenden) an ultimatum, and Anne (Kiele Sanchez) fully embraces her fling with Rose's 19-year-old classmate, Zach (guest star Andrew Keegan). Meanwhile, Ginnie and Bob sit down with an attorney to draw up their wills, but quickly discover they have completely different ideas of who should be the guardian of their child in the event something should happen to them.

Ginnie learns that Bob is working with one of his former girlfriends (guest star Jaime Ray Newman) at his job as a singer that he's producing an album for her, and Ginnie is not happy. Meanwhile, Anne sends Marco to Danny (guest star Dan Futterman) for a business deal. Marjee forces Jason to tell Trish (guest star Anne Ramsey) they are over before they officially begin their relationship. Rose can’t deny her feelings for Alex (guest star Chris Carmack) and strongly considers losing her virginity to him. Laslty, Rose confronts Joel (guest star Kyle Howard) about his sudden attitude adjustment ever since she rejected him for Alex (guest star Chris Carmack).

With Bob's sexy rock star ex-girlfriend, Kylie (guest star Jaime Ray Newman), staying at the loft, a pregnant Ginnie finds herself jealous and questioning Bob's intentions. Meanwhile, Rose decides to take Alex (guest-star Chris Carmack) home for dinner, but is startled by her father's (guest-star Tom Irwin) strange behavior, and Anne and Marjee commiserate over their boy troubles with Marco (Victor Webster) and Jason (guest-star Julian Ovenden), respectively. The Veronicas (sisters Jess and Lisa Origliasso) perform at Rose's college hangout, Brew Skies coffee house.

Ginnie is devastated when her doctor informs her that pregnancy complications will prevent her from attending her father’s (guest-star Tom Irwin) wedding to Renee (guest-star Christine Ebersole), but Bob devises a plan to keep the family together. Anne encourages her ex-boyfriend, Danny (guest-star Dan Futterman), to come to the wedding even though she is taking Marco (guest-star Victor Webster) as her date, and Marjee is furious that Renee’s son (guest-star Peter Paige) ruined the sister’s surprise wedding gift by announcing his gift first. Meanwhile, Rose and Alex (guest star Chris Carmack) decide to ignore a strict drama school policy and audition to be movie extras in a local production