The series begins with the four Sorelli sisters in the midst of their very complicated lives together. Oldest sister Ginnie, a high powered attorney is having difficulty on telling her husband that they are having a baby. Ann is dealing with the fact that her longterm relationship with her boyfriend Danny (guest star Dan Futterman) may be over. Marjee is in a rut on finding a restaurant to host a Pug Dog Benefit featuring Jillian Barbaree that will have live dogs. Also, college student Rose is having a hard time telling the family that she has switched college majors from Pre-Med to the Experimental Theatre Wing.

The sisters are also dealing with the fact that their father, Joe (guest star Tom Irwin, "My So Called Life"), has just announced plans to marry his girlfriend, Renee (Christine Ebersole, Tony Award winner for "42nd Street"), a development that has left the women with conflicting emotions.

Ginnie and Bob pretend to be tourist for a day and travel all over Manhattan as the couple decides to make a list of all the things they want to do in New York City before the baby arrives, but the task reveals a secret that Bob has been keeping from his wife. Marjee is clashing with her new father Joe (guest star Tom Irwin) step-mother Renee (guest star Christine Ebersole) as Marjee moves back in with her father and Renee after being evicted from her old apartment.

In the other Sorelli sisters' lives, Ann agonizes over how to handle her emotional break-up with Danny (guest star Dan Futterman). Rose develops a crush on one of her classmates in actiong class, Alex (guest star Chris Carmack). During an acting seminar he manipulates her on stage as part of their assignment and embarrasses Rose. Alex tries to invite her to a party but rejects his offer due to her embarrassment. Rose gets some advice from her friend Joel to see if Alex is really into her.

With their father (guest star Tom Irwin) out of town for the Halloween weekend, the Sorelli sisters agree to hold down the fort at the family deli, but things get a little out of hand when Marjee decides to throw a huge party at the house. In the midst of the chaos, Anne realizes she still has feelings for her childhood crush, Marco (guest star Victor Webster).

Tension in the Sorelli family arises when Anne finds out that her sisters are still keeping in close contact with her ex-boyfriend Danny. Bob becomes more concerned about Ginnie's prenantal health and the baby. Marjee is having difficulty on the new living arrangements of her boss' boyfriend. Lastly, Rose gets her first asting gig in a play written by and starring her crush, Alex (guest star Chris Carmack).

With a family Thanksgiving planned in Ginnie and Bob's loft, Ginnie, Anne, Marjee and cook a traditional Sorelli dinner using all of their mother Francesca's (guest star Dana Delaney in flashback scenes) favorite recipes. The sisters also reminisce about memories of their mother. Meanwhile, Anne is frustrated over her feelings for Rose's classmate, Zach (guest star Andrew Keegan, “7th Heaven”); and Renee (guest star Christine Ebersole, Tony Award winner for “42nd Street”) is rushed to the hospital with a stress-induced asthma attack after Ginnie blows up at her.

After forcing Bob to return the car he bought as a surprise for her, Ginnie has a change of heart and decides to have Marjee teach her to drive instead. Rose's new relationship with Alex (guest star Chris Carmack) hits a bumpy patch when he questions whether Rose's best friend, Joel (guest star Kyle Howard), has feelings for her; and Anne quickly realizes she may have bitten off more than she can chew when her father, Joe (guest star Tom Irwin), asks her to help his emotionally troubled fiancée, Renee (guest star Christine Ebersole). Rose questioneds her sisters about her realishonship with Alex

With Christmas festivities in full swing at the Sorelli house, Rose is torn between the two men (guest stars Chris Carmack and Kyle Howard) in her life, while Marjee finds herself in unfamiliar relationship territory when she realizes she may be developing feelings for her boss's boyfriend, Jason (guest star Julian Ovenden). Meanwhile, Ginnie is thrown for a loop when Bob announces at the last minute that his parents - most notably his cold-as-a-fish mother (guest star Judith Ivey) -- will be joining them for Christmas, and Anne is put in an awkward situation with her father, Joe (guest star Tom Irwin), and Renee (guest star Christine Ebersole), who is keeping a big secret.

Ginnie is devastated when her doctor informs her that pregnancy complications will prevent her from attending her father’s (guest-star Tom Irwin) wedding to Renee (guest-star Christine Ebersole), but Bob devises a plan to keep the family together. Anne encourages her ex-boyfriend, Danny (guest-star Dan Futterman), to come to the wedding even though she is taking Marco (guest-star Victor Webster) as her date, and Marjee is furious that Renee’s son (guest-star Peter Paige) ruined the sister’s surprise wedding gift by announcing his gift first. Meanwhile, Rose and Alex (guest star Chris Carmack) decide to ignore a strict drama school policy and audition to be movie extras in a local production