Brook tells Luffy that he is glad to be alive and asks if he can join the crew, which Luffy approves of. All the Straw Hats are shocked by this, except for Zoro, who is sleeping, and Robin, who knew Luffy would accept him no matter what, but they nevertheless welcome him to the crew. Two days later, Usopp and Franky make a grave for the dead Rumbar Pirates, and Zoro lays the broken Yubashiri at the grave. Nami gets a Vivre Card from Lola, which points the way to Lola's mother, a pirate in the New World. Luffy takes out the piece of paper he received from Ace, which is also a Vivre Card, and learns that as it is burning and shrinking, Ace's life is in danger. Believing that Ace can get out of trouble on his own, Luffy decides to head onward rather than go to rescue him, and the Straw Hats sail away from Thriller Bark. As the Luffy and his crew sail away, three enormous and mysterious figure appears in the fog, looking over Thriller Bark.

The crossover starts on Toriko E99 Run, Strongest Team! Toriko, Luffy, and Goku! (I)

Luffy's recent exploits make their way around the world! The reputation of this mighty pirate begins to grow as all eyes look towards the Straw Hats' next move! Also - German 66 leaves an artifact behind which excites the crew!

Luffy's group delivers the stolen food cart to Okobore Town and Luffy also gives the residents clean water. After Luffy parted ways with Tama and Speed, Law takes the group to the ruins of Oden Castle.

After his defeat, Luffy is sent to a prison in the Udon region. Kiku returns to the mountain where Oden Castle was destroyed and discovers that the group there managed to escape the destruction. Franky, Robin, Usopp, and Zoro read the news about Luffy's fight with Kaido. Inuarashi and his group discover Tama alive and take her into the forest. At the prison in Udon, Luffy meets Kid again.

Luffy and Old Man Hyo try to climb up the wall and break out of the Excavation Labor Camp, but Queen the Plague stands in their way and gives them a hard time! Meanwhile, Nami and Robin experience a public bathhouse along with Shinobu and come to know about the Land of Wano’s great yakuza boss.

After claiming responsibility for Kin'emon's secret message, saying it was a prank, and casting doubt in the Rasetsu prison guards, Yasuie meets a brutal end as Orochi and his men shoot him to death. As the Ebisu Town citizens "laugh" over Yasuie's death, Hiyori reveals to Zoro that they were affected by the fruits known as SMILE.

Luffy attempts to defend against Big Mom's attack, but she sends him and Hyogoro crashing into a wall. They both survived, but Big Mom continues attacking Luffy, chasing him around the Prisoner Mines. Queen regains consciousness and he comes up with a plan to take down Big Mom. Once Luffy and Big Mom return to where they started, Queen uses a dive bomb attack and strikes her in the head. The attack appears to have failed and Big Mom regains her memories.

Raizo retrieves the keys to Kawamatsu's cell as well as his sword. The ninja later gives them to him, and Kawamatsu frees himself. After Raizo, Kawamatsu, and Kikunojo reunite, they joined up with Luffy and Hyogoro in fighting the Beasts Pirates. However, the Beasts Pirates continue infecting prisoners with Excite Bullets.

Haccha, a supergiant Number, joins in and the pursuit of Luffy and the others becomes even more intense. Meanwhile, Kin’emon changes his strategy and his group tries to infiltrate the castle from its side, but there is an unexpected change of the floor plan which coincidentally makes Sanji excited.

The Akazaya members deliver a crushing blow to Kaido. Luffy and Yamato try to back them up, but Ulti stands in their way and Big Mom spots Luffy. Meanwhile, Nami and Carrot free themselves from their enemies and move on to take back Zeus!

Dogstorm confronts his sworn enemy who destroyed his country. Meanwhile, Cat Viper faces Perospero who is responsible for Pedro’s death. At Tokage Port, Momonosuke roars with his determined eyes.