After surviving the attack by Colleen, Sean's physical and emotional well-being are still feeling the effects. Meanwhile, Christian receives some disturbing news after lending Liz some moral support with her breast cancer scare.

After being rejected by Kimber on account of his post-surgery scars and with his chemotherapy making him sick, Christian seeks support from Liz, which leads to a surprising sexual encounter between them. Sean discovers his new lover (Jaime Ray Newman) has a disturbing fetish, and further alienates Julia and Matt when they learn that he has been faking his need for a wheelchair. Raj has a life-altering sexual encounter with the wife (Beth Gargan) of McNamara/Troy's latest patient.

Sean tries to deal with his feelings for Julia, while Liz and Christian analyze their relationship and Christian meets someone who understands what he is experiencing with his breast cancer.

Matt becomes envious of Sean and Raj bonding together. Christian and Liz give their relationship another chance. Raj's father pays a visit to see his son.

Aidan Stone, a down-on-his- luck writer who has written a biopic about Sean, wants to use it to relaunch his career. Christian is asked by Kimber to give a Botox injection to her daughter so she has a better chance at becoming a baby model. Sean and Christian have been asked by a yoga instructor to perform a procedure in which neither have ever done before.

A horribly disfigured man is worked on by Christian and Sean. Meanwhile, Sean hopes to strike up a relationship with the new anesthesiologist Teddy Rowe, and Christian goes for a check up with his oncologist.

Christian decides to employ Dr. Logan Taper for the practice, while Sean is revisited by a former client from Miami to have plastic surgery so she can attract suitors once her husband dies.

As Christian and Liz make their wedding plans, he also looks for a new cancer treatment. Meanwhile, Ram Peters drops Kimber for a newer model, while Teddy informs Sean that someone close to her is gone, and Sean and Christian repair a couples neck wounds which look strikingly similar at McNamara/Troy.