A noblewoman who was forced into prostitution after her fiancé and family were murdered at their wedding, asks Itto to kill the man responsible, a spurned former suitor.

Ogami Itto and his young son Daigoro arrive in a town known for its hot springs, but the entire village has been taken over by a gang of murderous bounty hunters.

Poisoned after a surprise attack, Ogami must face a deadly gauntlet of Yagyu assassins in order to fulfill a promise made to a dying man who saved Daigoro.

A meeting on the Assassin’s Road causes Itto to remember the events leading up to his wife’s murder, and why he chose to bring his son with him on his mission of vengeance.

Multiple stories interweave as Daigoro becomes lost while seeking medicine for his father and is befriended by a young woman who is being sold into service by a loan shark.

When his father is delayed for multiple days after an assassination goes awry, a desperate Daigoro wanders off and falls into the hands of a ruthless gang of criminals.

Itto is hired to assassinate a gunsmith who has reportedly developed a repeating rifle, a weapon that could completely destabilize the balance of power in Japan.

Itto accepts an assignment to stop a shipment of gold, assassinate a government official, kill an entire team of covert agents and prevent a small clan from being framed.

As Lord Yagyu prepares to send his last and strongest son, Gunbei, to kill Itto Ogami, the events of Gunbei and Itto's previous duel are revealed.

A scheming magistrate's plan places Itto in the middle of a war between two Yakuza families, one of which is lead by the daughter of the leader of the other.

While the Yagyu set a trap for Itto, a group of con artists pose as Lone Wolf and Cub and a disgraced Samurai takes on the role of Ogami.

As Itto waits for an opportunity to assassinate a sadistic Lord, he and Daigoro observe the life of a young boat woman who must sell herself to support the man she loves.

While Itto tracks down the killers of a young woman's entire family, Daigoro becomes caught up in a policeman's hunt for a notorious female pickpocket.

Itto accepts a job that will protect the location of a secret gold mine, but the task is complicated when a rival swordsman takes Itto's target's son hostage.

Itto must deal with a well-wishing doctor and a group of shadow ninja when he's tasked with killing a group of assassins who're rgeting the Shogun's lover.

Itto returns to a spot on the banks of the Shinobu River where he once executed the lord of a Clan, and faces a samurai he defeated in a duel four years earlier.

Government officials convince Asaemon the Beheader, one of the few swordsmen in Japan with a level of skill close to Ogami’s, to kill Itto in combat.

Itto meets Sakon Shino, a beggar samurai who has given up killing for a life as a street performer. Shino urges Itto to give up his assassin life, for the sake of his son.

The Lone Wolf and Cub have their work cut out for them when a seemingly simple job turns into a deadly game of lies and intrigue.

The Lone Wolf and Cub rescue a woman who has sold herself into prostitution in order to stage her revenge on her murdered brother’s evil fiancé.

Desperate to keep their clan from being dissolved, the family of a murdered Lord fake the real killer’s murder and ask Itto to verify their false claim.

Assassins from the Kurokuwa clan stage a non-stop series of attacks that lasts for days, slowly steering an exhausted Lone Wolf and Cub into a deadly trap.

Itto is hired to kill a samurai who has allegedly turned his men against Lord Norikatsu, but the true reasons turn out to be far more complex and deceptive.

Ogami mysteriously joins a group of “the unclothed”, men with the unusual job of carrying people and baggage across a river where bridges and ferries are forbidden.

After being thrown off a cliff during a battle with the Yagyu assassins, Daigoro searches for his now missing father while avoiding his family’s many enemies.

Itto tries to follow the trail left by his missing son, Daigoro, while fighting off the forces of Lord Retsudo and his Yagyu assassins.

Retsudo has powerful friends, including the Shogun himself. To deal with Itto once and for all, the Shogun places the Guards of the Black Gate under Retsudo’s command.

The magistrate increases the reward for the Lone Wolf’s head when bounty hunters demand a higher price for such a dangerous target.

A failed ambush plays right into Ryuza’s hands. Can Itto survive the bounty hunter’s “genuine hell”? Meanwhile, Torizo cross paths with Itto once again.

Itto regularly accepts assassination requests, but rarely does he receive a cancelation. What does the Yagyu have to do with it and what is the extent of their influence?

Osen is determined to escape a Yakuza-run brothel. Will an encounter with the Lone Wolf finally give her the chance she seeks?

Believing that the Daijoji clan is acting under the orders of the Yagyu, Itto attempts to avoid needless bloodshed. But is that a luxury an assassin can afford?

The Lone Wolf wanders, cutting down any bounty hunter in his path. Now, it is Akane’s turn. If she fails, her sisters must succeed in her place.

An old woman finds a small boy trying to catch fish by the shore. She teaches him how only to discover the boy wanted to feed his sick father, who is known as the Lone Wolf.

People always have a reason for their actions. Some desire to save others. Others desire to save themselves. As for Itto? There is only the grudge.

The latest plan to ensnare the Lone Wolf involves restricting the number of bounty hunters sent after him.

Legend tells of a flower that would bring happiness to any who picked it. However, can there be any happiness for Miyo?

Sakai would rather sacrifice his lands than have his men senselessly cut down by the Lone Wolf in someone else’s crusade. It is precisely for that reason he must now die.

Itto’s inevitable journey to Edo is nearing its end, but there are only a few routes left that he can take. His enemies know this and prepare...

An intentional snub signals that The Shogun’s patience towards Retsudo is wearing thin. With only 10 days to kill Itto, Retsudo hatches a plan with an unlikely ally.

Oshun and Abe prepare to snare Itto and Daigoro in their trap. They don’t care how far they have to go or whom they have to hurt!

Abe learns the truth and takes matters into his own hands as Retsudo schemes. Meanwhile, Itto runs into a lordless samurai.

Cornered and desperate, Abe flees from Retsudo’s wrath. The poisoner’s only hope? Assassinating Itto before his pursuer catches up.

Itto and Retsudo’s paths will cross at the Haccho river. Will that be where their fates are finally decided?

The floodgates are opened, and the city of Edo is in danger. In the face of such a catastrophic threat, two mortal enemies are forced to work together.

Abe watches as Itto and Retsudo resume their duel, hoping the poison he applied to their swords will finish them off. What will the two do when they realize this treachery?

Retsudo is summoned to face the shogun. Meanwhile, the bounty on Itto’s head may have been rescinded, but that doesn’t mean everyone will tolerate his presence.

Itto waits while Retsudo is on trial. Meanwhile, the Grass starts mobilizing...

No matter what Abe does, Retsudo somehow finds a way to foil his assassination attempts. Abe may have the upper hand for now, but Retsudo is a patient man…

Itto and Daigoro’s paths cross with a man known as Bunshichi. What’s his reason for stealing all that money?

The fate of the Yagyu and the Grass are intertwined; One cannot exist without the other. It is for that reason the Grass launches one, final attempt on Itto’s life.

Itto has long straddled the line between life and death, but it is not a path one can follow forever. In the end, on which side of the line will Itto finally find himself?