The program tells the story of a handful of brilliant, obsessed surgeons and researchers who have pursued the target of a practical artificial heart for decades.

The program investigates the mysterious disappearance -- and, half a century later, reappearance -- of Stardust, a civilian aircraft that crashed in the Andes in 1947.

The program investigates the brave new world of assisted reproduction.

In October and November 1999, NOVA journeyed into ice-choked Antarctic waters and onto the shores of rugged Elephant and South Georgia Islands as we followed in the footsteps of Sir Ernest Shackleton. This legendary explorer's 1914-1916 Endurance expedition is one of the greatest survival stories of all time. Then, in April 2000, we returned to document Shackleton's final trial -- the crossing of South Georgia -- by three of the world's most distinguished mountaineers, Reinhold Messner, Conrad Anker and Stephen Venables. Follow the expeditions as they unfolded in real-time on this Web site, and also watch for a NOVA Giant Screen Film Shackleton's Antarctic Adventure, as well as a NOVA program, "Shackleton's Voyage of Endurance," which originally aired on March 26, 2002.

Toxic caverns teaming with strange life-forms spark a brand new theory about how caves form.

For nine months in 2000, Tom Hart Dyke was a captive of guerrillas who seized him while he was collecting wild orchids in the Colombian rain forest. Now Hart Dyke is at it again in the most orchid-rich and one of the most politically unstable parts of Irian Jaya, the western half of the island of New Guinea.

Nova investigates the impact of forces that are radically changing populations in both rich and poor nations.

Experts explore the mysterious story of five siblings living in a remote Turkish village.

Experts investigate how a mysterious "second genome" helps determine our biological fates.

NOVA takes viewers on a journey from the Galapagos Islands to the Arctic, and from the Cambrian explosion of animal forms half a billion years ago to the research labs of today. Here scientists are finally beginning to crack nature’s biggest secrets at the genetic level. And, as NOVA shows in this absorbing detective story, the results are confirming the brilliance of Darwin’s insights while exposing clues to life’s breathtaking diversity in ways the great naturalist could scarcely have imagined.

What will it mean when most of us can afford to have the information in our DNA—all three billion chemical letters of it—read, stored, and available for analysis? In "Cracking Your Genetic Code," NOVA reveals that we stand on the verge of a revolution. We meet cancer patients returned to robust health and a cystic fibrosis sufferer breathing easily because scientists have been able to pinpoint and neutralize the genetic abnormalities underlying their conditions. What are the moral dilemmas raised by the new technology? Will it help or hurt us to know our genetic destiny? What if such information falls into the hands of insurance companies, employers, and prospective mates? One thing is for certain: The new era of personalized, gene-based medicine is relevant to everyone. Soon, all of us may be deciding whether to join the ranks of the DNA generation.

Alzheimer's ravages the minds of over 40 million victims worldwide. Join scientists as they untangle the cause of this tragic illness and go behind the scenes of major drug trials to discover the therapies that may slow and even prevent the disease.