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A seller stops by the shop to gather offers on what he claims to be a genuine shrunken human head; a composer of black metal looks to a dark inspiration for his craft; a performance artist offers up a concert on his unique trumpet.

At Obscura Antiques and Oddities, shop regular Laura Flook stumbles upon a disturbing, mysterious tonic -- made with actual testicles. Meanwhile, when a customer can’t part with his beloved "pets," Ryan accepts a challenge to "rebuild" them from recently unearthed remains. He hits a serious snag when pieces of the formerly-purring pair are missing, forcing him to take some artistic liberties that the customer finds intriguing. Later, when a seller offers to part with what he calls a mummified human ear, Mike and Evan must call in their expert to find out if it’s the real deal.

When a seller brings three jars of grotesque, deformed pigs to Obscura Antiques and Oddities, Mike thinks they may be the perfect items for a restaurant owner up the street. When they are turned down for being "unappetizing" Mike and Ryan must scramble to find a replacement piece for the eatery. Meanwhile, Evan unexpectedly meets a kindred spirit: a customer who purchases one of her favorite, painstakingly restored pieces of Victorian hair art. And a mysterious artist who paints in his own blood makes a deal on a WWI blood transfusion kit, and takes Mike and Evan on a tour of his work.

At Obscura Antiques and Oddities, regular customer Edgar is looking for a very special desk lamp. When Evan presents him one made of a baboon’s paw, he feels it may be too spooky, even for this eccentric buyer. Then, Ryan gets a lesson in love a beautiful bone artist stops in to try to sell an articulated rooster skeleton. Ryan plans a romantic date, but things take a turn for the worse when he brings her to meet another bone artist -- and his flesh-eating beetles. Meanwhile, a seller tries to peddle teddy bears (made of her boyfriend’s sweaty belly button lint) to Mike and Evan.

At Obscura Antiques and Oddities, Mike and Evan are intrigued when a sleep-deprived customer stops in to unload a nightmarishly large bat -- and its huge fangs. Then, a buyer who turns century-old inventions into new, working technology with Victorian flair sends Mike and Evan on the hunt for a quack medical device that he can use as a video game controller. Later, Mike takes a chance purchasing a very creepy, mute "talking doll" created by Thomas Edison, then reunites the doll with its voice box to hear what it might have sounded like 100 years ago.

At Obscura Antiques and Oddities, Mike and Evan are speechless when they witness an artist boldly attempt to steal the store’s dust -- and then sell it back to them. Then, a high-end buyer wants Mike to create a massive piece of specialized taxidermy. Mike takes the challenge, but finds the cost to create it is way over the customer’s budget. Mike must decide whether to renege on the deal, or take a gamble on a potentially huge loss for the store. Later, an amazingly flexible grandmother falls in love with an adorable stuffed feline, and performs an incredible act of contortion to get a discount.

A bizarre medical specimen is sought for a photo shoot; an artist happens upon a corrective device; an impalement artist purchases a throwing knife once owned by Harry Houdini.

At Obscura Antiques and Oddities Evan and Ryan meet an artist whose favorite medium is bodily secretions -- but now she wants to go in a different direction, and needs something she can really sink her teeth into. Then, a sideshow performer requests a usable prop from Coney Island's heyday. Later, customers come to the shop with what they think is an old leather diving helmet, only to find that there is more to this helmet than they thought.

While on the hunt for items for Obscura Antiques and Oddities, Mike locates an old plasticized piece of human anatomy, and finds it to be more of an eye-popping experience than he expected. Then, Mike’s wife Kris recruits Evan and Ryan to find the perfect birthday gift for Mike. Later, Actress Chloe Sevigny wanders in, and finds a lewd old-time gag that she gets a rise out of.