Kitty guards a devastating secret that could change the Walker family forever. Meanwhile, Nora and Holly work together to thrown an engagement party for Justin and Rebecca; Tommy remains in Mexico; and Sarah heads to France.

As Robert worries about news of his recent heart attack leaking to the press, Kitty struggles with an untold secret that will deeply affect their marriage and bring the Walker family together like never before. Meanwhile, Kevin and Scotty discuss the real possibility and challenge of surrogacy.

Kitty, Robert and Nora struggle to accept Kitty's cancer and to come to an agreement on the best possible treatment, but as they prepare to share the news with the entire family, a surprise visitor from afar makes the burden a bit easier to bear.

After returning from France, Sarah manages to distract Kitty through her chemo treatments by using tales of her romance with a French artist. Meanwhile, Justin has problems with his anatomy class and seeks his professor for help with surviving the semester with his teenage genius lab partner.

Kitty's life is in jeopardy as the Walkers frantically search for a bone marrow donor.