After moving into an apartment, Blythe Baxter gains the ability to communicate with animals after falling in a dumbwaiter. There, she meets a group of pets who reside in a day camp area of a pet shop, who enlist her help when the store is on the verge of running out of business.

In the second part, Blythe hosts an animal fashion show featuring the pets in order to drive revenue to the pet shop. Meanwhile, the Biskit twins Brittany and Whittany plan to stop Blythe by embarrassing her during the climax of her show.

Blythe stumbles to fix a botched haircut on Zoe, while the other pets urge Minka to purse the life of an art superstar, and get out of hand when they overestimate her artistic endurance.

Blythe uses the pets as diversions in order to rescue Zoe's sister from inside Largest Ever Pet Shop, an expansive pet store retail chain owned by the Biskit twins' father, Fisher Biskit.

Blythe earns the gratitude of the Biskit twins after defending them against a bully during gym, but ends up being forced from talking her other friends. Meanwhile, Pepper is inspired to use insult comedy as part of her stand-up comedy schtick, but takes it too far on Penny while being unaware of her sensitive feelings.

Blythe rejects the notion of her dad going on a date to a charity ball, while Penny Ling struggles to voice her disapproval of an outfit Blythe designs for her to wear at the ball along with the rest of the pets.

Suspecting that he has become too serious for his own good, Russell loosens up by creating an alter ego, dubbed "Fun Russell". Meanwhile, Blythe finds her friend Sue mimicking every aspect of her personality unsettling.

Blythe stumbles upon some keys belonging to her crush, Josh Sharp, and goes searching for him using Sunil's precognition. When he assumes she has gotten lost due to his own lack of faith in his psychic abilities, he enlists the help of his friends, along with larger-than-life parrot Esteban Banderas.

While on her way to meet with her friends at a flash mob, Blythe gets trapped in the dumbwaiter along with Zoe, Pepper and Minka. While Penny Ling tries to attract the attention of the boys to get them out from the dumbwaiter, Zoe and Pepper start to fight, and within their compact space, Minka's claustrophobia is triggered.

Blythe attempts to be the peacekeeper between Zoe and her old rival Madame Pom when arrives at day camp, all the while Penny Ling and Vinnie nearly destroy the shop while practicing for their new group dance routine. Likewise, Mrs. Twombly goes on a rampage in search of her favorite cleaning spray.

The pets suspect a Siamese cat visiting the day camp is preying on Mrs. Twombly. Meanwhile, Blythe encourages the Biskit twins to join their mathlete team after she overhears them using narratives of their daily life to solve complex math equations.

Vinnie gets to tour the set of his favorite dance competition show, Shake a Leg. When his dance performance in front of the show's judges gets harshly rejected, he tearfully abandons Blythe into the streets, where he befriends an ensemble of street-dancing lizards. Meanwhile, the pets stumble around trying to find a decent spot for their remote control.

Sunil is mistaken for Shahrukh, a famous movie mongoose hailing from India. The pets bend over backwards to appease him, but quickly lose their patience at his pampered behavior during his stay at the day camp.

Zoe, temporarily bandaged due to an embarrassing pimple on her nose, asks Penny Ling to pass along her romantic feelings to her crush, Digby, during his stay at the day camp. Meanwhile, Russell hides in Blythe's backpack, wanting to pursue an education, but gets lost within the corridors of her high school.

Youngmee's Aunt Christie opens a confectionery store adjacent to Littlest Pet Shop, and the pets meet pet Buttercream Sunday, a hyperactive rabbit, who invites them to overindulge themselves on the sugar-filled treats located in Christie's pantry.

Surrounded by guilt, the pets try to prove Blythe's innocence after she is accused of sending Aunt Cristie's truck careening down the street while meeting Buttercream's alley cat friend, Sugar Sprinkles.

Minka tries to befriend an antisocial tortoise named Olive Shellstein, who is dropped off at the day camp, but stumbles to get her out of her shell before she has to leave. Meanwhile, Roger surprises Blythe at her high school, wishing to spend the day together.

Blythe enlists the pets to retrieve her new favorite necklace that fell inside a vat of batter used for filling a huge cupcake order with Youngmee. This proves difficult for them, when they discover the order was placed by Fisher Bisket for his twin daughter's "quarter-birthday" party.

Vinnie accidentally falls into a dumpster while trying to catch a fly and is transported to the dump, where he encounters a rat that helps him get back to the pet store. Blythe contracts the common cold and can no longer understand the pets, so the pets try to cure her.

Russell, Zoe, and Vinnie, along with Buttercream, try to retrieve a recipe stolen from Blythe by the Biskits, who plan to use it for a baking competition hosted at Blythe's school. All the while, Vinnie has a vision of cakes occupying the world.

Zoe begs for Blythe to enter her in a reality television series based on a beauty pageant for dogs. What starts off as enjoyable starts to consume Blythe, who becomes driven by winning the pageant, much to the dejection of Zoe.

Blythe discovers Mrs. Twombly's past as the inventor of a unique martial art. Meanwhile, Pepper's comedy idol, Old Bananas, comes to visit the day camp, but finds herself struggling to amuse him with her jokes, in order to earn his signature thumbs up of approval.

Sunil and Vinnie hear howling noises coming from inside the pet shop, and suspect that their friends have turned into werewolves. When Mrs. Twombly finds she has been outbid at an online auction for a highly coveted doorknob by her rival, Fisher Biskit, she takes Blythe and herself for a visit to his mansion to find its whereabouts.

Vinnie's tail falls off in an act of autotomy, and after a series of trials to find an adequate replacement for it, he is shocked to find that he becomes better at dancing without one. Meanwhile, Zoe and Pepper become rivals over the theme for a party meant for Penny Ling.

While searching for Mrs. Twombly's missing glasses, Blythe comes across Shivers, a fast-talking squirrel with a hoarding problem. When Blythe and the pets realize Shivers is at fault for items missing from Littlest Pet Shop, they try to help him face his issue.

When Blythe gets accepted into the junior program at a fashion school, she, along with her family and friends from school and at Littlest Pet Shop, have to bode with the anxiety of her leaving.

A few months pass since Blythe left for her summer junior program, but her dream school is not as exciting as she thought it would be when all the campus talks about is fashion. Meanwhile, aching to see her in person again, the pets come up with a plan to visit Blythe while she is away at fashion camp for the summer.

Blythe accidentally starts a new fashion craze with her wild "Nest Hat", inspired by a nest that lands on her head. To her shock, she finds an unhatched egg laying inside of it. The pets are chosen to take care of the newly hatched chick using their animal instincts, while Blythe tries to find the chick's mother. However, her plans fall in the hands of the Biskit twins, holding her hostage while trying to exploit her new-found fame.

Russell becomes ecstatic as he reviews the plans for his first slumber party while with Blythe at the day camp. Jealous that they are not invited, Sunil and Vinnie make plans to crash their party. Meanwhile, Mrs. Twombly notices her supplies are being consumed by something, and jokingly cites a poltergeist as the cause of it, which awakens Russell's superstitions about a ghost he read up on. Later, Sunil and Vinnie's attempt by to break in to the pet shop sends the city without power, causing Russell to hallucinate an octopus-like creature trying to devour him.

An endangered specimen of cobra escapes from within a pet carrier of Fisher Biskit, after finding a potential buyer for it. Meanwhile, after three straight days of rain, the pets go on a walk with Blythe to their public park. Sunil breaks away from the group, and finds himself among a group of tribal raccoons, as well as a pigeon who can understand them. There, they find the escaped cobra, and Sunil saves them after confronting it using his primal instincts. They celebrate, and the raccoons force Sunil to stay with them indefinitely as their king.

Mrs. Twombly is inspired to set up a booth for a self-proclaimed pet psychic by the name of Finola, after she demonstrates her mind-reading on the pets by describing their personalities (while getting them entirely wrong). However, her predictions for other customer's pets break the bank for Mrs. Twombly; all her prognoses revolve around the pet wanting a brand of dog food. Meanwhile, the pets suffer while trying to mold themselves into Finola's personality readings, trying to avoid disrupting her partnership with Mrs. Twombly. When Blythe sees what is happening, Finola's pet sugar glider, Sweet Cheeks, may have the answer for Blythe as to what his owner's business really is.

The host of a reality television series informs Mrs. Twombly of buried treasure located beneath Littlest Pet Shop, belonging to one of her ancestors. Their efforts at excavation quickly become the source of irritation for Blythe when they start causing property damage, and the source of outrage for Pepper, who takes the crew's map to show to the pets. There, the roots of Littlest Pet Shop are uncovered, and the story of Henrietta Twombly is told in the form of flashbacks.

On nail-clipping day at the day camp, Sunil becomes anxious about being clipped and cowers in fear in front of Blythe's friends. Jasper, who finds his worried facial expression cute, takes a picture of him with his phone and edits it into an image macro. Soon after he uploads the macro on the Internet, Sunil and the day camp attracts media coverage from across the globe. His attention becomes the source of jealousy for Zoe, and the vanity of the Biskit twins, who produce a music video of themselves in an attempt to become viral.

When Blythe's enters her dress designs for the The Big, Feathered Parade at the parade's warehouse, she is promptly denied due to age restrictions. There, she comes across Ramon (voiced by Colin Murdock), the head designer of the parade, and his Common Myna, Desi (voiced by Brian Drummond). Ramon becomes impressed upon seeing her designs, and decides to steal them by switching her portfolio with his identical one. Blythe notices the replacement, and when she sees her designs being used on every aspect of the parade the next day, she sets off to reclaim ownership of them. Meanwhile, when Vinnie pairs with Zoe to quench his obsession, Bruce the iguana (also voiced by Murdock), he struggles to find a water bottle big enough for Bruce.

After losing a ball while playing catching, Minka and Penny Ling try to retrieve it when it rolls into a natural history museum. Blythe tries to retrieve the two without losing all the other pets, but finds out that the museum disallows animals. She conceals the rest in her bags and backpack, but as she spots the two that were missing, Zoe flees from her bag upon inspection from the museum's security guard. Now with three of the pets missing, Blythe must manage to find them all, eventually losing the rest in the process: Sunil and Vinnie in the taxidermy section, and Russell in a supply closet.

Roger reveals to Blythe that he has just submitted Blythe's pet backpack to Mona Autumn, a critic for the top fashion magazine, Très Blasé. Knowing that Autumn's critiques are notoriously harsh, she starts panicking about her interview, ignoring the pet's problem with a new visitor, Wiggles McSunbask (voiced by Colin Murdock), a juvenile alligator who soon takes over the day camp. When Blythe's designs are rejected by Mona, as feared, and suggests that she peruses another career, she grows depressed, much to the sadness of Roger and the helplessness of the pets.

Blythe must trade in her scooter for a sales kiosk in order for her to enter enter the International Pet Fashion Expo. Meanwhile, Roger's airline launches a "Pet Jet" service, with the pets using it to launch one of their largest fantasies yet.

Slow business prompts Mrs. Twombly to shoot a commercial for Littlest Pet Shop.

Penny Ling invents a convoluted tale during a story-creation session among the pets.

When Blythe fills in for Zoe's owners and accompanies her to a dog show in Paris, they suddenly find themselves smitten; Blythe with the city and Zoe with a mime artist dog named Philippe.

Penny Ling decides to give Sunil a superhero outfit and make the two of them a superhero duo in order to help Sunil overcome his fears. Sunil pretends to rescue his friends, which becomes a problem when he believes he actually has superpowers. Meanwhile, with the help of Russell and Sugar Sprinkles, Blythe helps Youngmee and her aunt Christie find an ideal parking space for the Sweet Delights truck, only to compete for it against the Biskit Twins.

Blythe must babysit Buttercream while trying to finish reading a book simultaneously, while Pepper struggles to socialize with a visitor to the day camp whom she finds herself smitten with.

When Blythe and the pets travel to Shanghai to attend a ceremony honoring Mrs. Twombly as originator of Kung Fu Quilting, Penny Ling is reunited with family she never knew she had. Meanwhile the pets prepare a Chinese dragon dance to ward off spirits.

The results of DNA testing for two of the pets cause panic in the day camp. Meanwhile, Roger is laid off from his job as a pilot, and assumes the role of the Biskit twin's personal assistant and chauffeur instead.

The pets are driven to madness trying to identify a hum resonating from inside the shop, while Blythe runs for class president against the Biskits.

An old nemesis shows up to defeat Blythe and the pets competing in the Carnival parade in Rio.

Roger takes Blythe and the pets to a camping trip in search of Bigfoot.

Russell tries to reconcile Sunil and Vinnie's friendship after an emotional falling out sparks between them.

Russell and Blythe find themselves in a (partially imagined) state of solitude.

The pets try to convince Minka that she is the first monkey to land on Mars, and Pepper asks Blythe for input for her stand-up comedy act.

Blythe stresses over the upcoming International Pet Fashion Expo when she is asked to do a photo shoot for Très Blasé.

At the Pet Expo, the Biskits sabotage Blythe at every turn, fueling superstitions over her entry. At the end, the Pets and Blythe are able to recover her stuff and exposes the Biskits' sabotage. The Biskits' butler confesses that they made him take part of their scheme. They fired their butler. The butler became a photographer. The Biskits are humiliated and expose for their crime. Blythe won the International Pet Fashion Expo. Pets got their faces at the magazine.

Russel challenges Vinnie and Sunil to entertain Mr. VonFuzzlebut, a raccoon who is placed at the day camp. As soon as he arrives, however, he enters a deep sleep, so Vinnie and Sunil must pretend to entertain him without Russell knowing. Meanwhile, Fisher Biskit encounters difficulty finding the reason behind Littlest Pet Shop's recent success, so he sends his daughters to find out.

Mrs. Twombly tries to increase business at the pet shop. Meanwhile, the pets see a UFO and Blythe tries to help figure out what it really is.

While at a photo shoot for Tres Blasé magazine, Zoe and Russell take on a passive-aggressive pet model named Tangier, who tries to sabotage Russell; simultaneously, Blythe substitutes for an assistant of Mona Autumn, the magazine's editor.

Blythe tries to resolve her feelings for Josh Sharp; meanwhile, Russell becomes the subject of a love spell while trying to stop a secret pet "cupid".

Stolen merchandise from Largest Ever Pet Shop lands in Blythe's dumbwaiter. She asks Pepper and Vinnie to investigate. and their search for the culprit leads to the discovery of an elaborate tube system dug out by two hamsters, Dodger and Twist.

Pets from all over Downtown City find out that Blythe can understand them and come to her for advice, but a Korean-speaking ferret causes Blythe to doubt her abilities. While Blythe tries to help the ferret, she puts Zoe and Russell in charge of helping the other pets, where they let their egos get the better of them.

Penny Ling is excited to meet the host of her favorite show, but becomes upset when the host is afraid of her. Now Blythe must find Sunshine Sweetness (voiced by Kathleen Barr), a purple gorilla, so that she understands why Tess is afraid of pandas and gorillas.

Blythe brings Penny Ling and Vinnie to school for Pet apperication day and tries to encourage the Biskits to keep twin chinchillas they have owned for one day; meanwhile, Sunil tries to convince Minka that he is also an expert painter.

Arguing koalas wreak havoc at the pet shop; meanwhile, Brittany ignores Whittany after she scores higher marks on a test.

Blythe finds out that Josh Sharp works at Largest Ever Pet Shop. Meanwhile, the pets must rescue a visiting goldfish who fell into the sewers.

When the Biskits invite Youngmee and Blythe to their party, the pets must disguise as a tall man whom Fisher Biskit thinks is real.

When a jungle curse shrinks the pet shop to dollhouse size, a nice young girl thinks the miniature pets are toys. Zoe and Blythe must find a way to stop it.

Blythe must reveal her secret in order to save Youngmee's appearance on television and their friendship.

Blythe and Zoe spend a weekend at the Biskits' winter chateau, while the pets try to cheer up a homesick penguin.

A massive snow storm hits Downtown City, trapping Blythe and the pets at Littlest Pet Shop and things get tense with the pets at each other's throats. Meanwhile, Roger keeps getting lost while trying to dig through the snow to get to the pet shop to save Blythe.

When Russell sprains some quills and ends up in a traction ball, he finds himself with nothing to do but stare out the back window where he is certain he catches Josh Sharp stealing Blythe’s discarded design sketches from the recycling bin.

Blythe second-surmises her frilly room in the wake of perusing a magazine about popular high schooler rooms while the pets get peppered by a curious kitten.

Blythe meets another young lady at the thrift shop and dismisses her old companions; Vinnie becomes friends with an arachnid.

Blythe and the pets help Cheep-Cheep, a cousin of Minka, when he believes his scientist owner invented a helmet for pets to speak with humans.

Roger’s super competitive sister, Mo, comes for a visit, bringing them a constant desire of outdoing each other.

Blythe and Mrs. Twombly help a friend to make a showplace out of her rundown pet hotel, in spite of Fisher Biskit's determination to close down the place.

The pets try to help a bashful peacock prepare for his big debut at the botanical gardens, while Youngmee tries to convince Blythe to use her ability to communicate with animals for the benefit of humanity.

Sue gets help from Blythe and friends to overcome a reluctance to accept an award in front of the whole school; Pepper's jealousy shows when the pets enjoy the company of a sweet-smelling skunk day camper.

When Harold, an obnoxious groundhog, arrives at the day camp, Russell cannot wait for the day to end but is horrified to discover it never does.

When Blythe's dream of holding a Pet Fest in Downtown City has a chance to become a reality, she must race against time to pull it all together.

Blythe must race against time to make her dream of having a Pet Fest a reality.

A giant tortoise visits the camp and shares some knowledge with Blythe, who's contemplating her life's calling.

The pets form a singing group and compete in a championship. Meanwhile, Blythe becomes preoccupied with her mom's journal and doesn't help look for Mrs. Twombly's missing doorknobs.

Youngmee seeks a perfect pet, so Blythe helps her search. Meanwhile, an unruly circus bear arrives at the camp.

Russell's dad moves in with him. Meanwhile, Blythe becomes friends with an elderly woman who wants Blythe to get to know her granddaughters.

The gang compete to tell the spookiest story. Meanwhile, Roger experiences extreme jet lag and mistakenly believes he's living out a nightmare.

Russell's excited to go to the Renaissance Faire, but then he learns corrupt activity is occurring at the event.

A sitcom about the pet shop is created, but Blythe fears this will expose her secret.

Blythe takes on another job as a sales clerk and lets her spending get out of control. Meanwhile, the pets grow annoyed with a difficult doll Blythe asks them to watch.

Blythe and Russell go camping on a very cold mountain. Meanwhile, Zoe develops a crush on a German shepherd.

The gang go to the beach, where Penny Ling meets a lobster focused on fitness and Blythe unveils her line of pet beachwear. Meanwhile, Sunil competes against Vinnie in a sand-castle contest.

Blythe and McKenna compete against each other on a fashion reality show. Elsewhere, the gang at the pet shop are puzzled by Sugar Sprinkles' odd behavior.

The Biskits get suspended from school thanks to Blythe, and she feels guilty about it. Elsewhere, Vinnie breaks Pepper's lucky rock, and Pepper wants to see him punished for it.

A dog must be rescued from its fraudulent owner. Meanwhile, the pets perform an episode of a TV show beloved by Russell.

Blythe assists Mrs. Twombly, who's getting ready to open a new coffee shop.

The Biskits make a vlogcast to rival Blythe's. Meanwhile, the pets believe that Penny Ling is leaving them.

Sunil and Vinnie get lost while at a sci-fi convention. Elsewhere, Minka attempts to unwind by following a new camper's Zen approach to life.

A canine refuses to compete in a dog show, baffling Blythe and Zoe. Elsewhere, Wiggles comes back to the day camp as a changed alligator who's worked on self-improvement.

Sunil's pursuit of happiness leads him through the city with the other pets. Meanwhile, Blythe tries to find her mom's journal after she loses it.

Underground bunny races become all the rage and Vinnie and Sunil get swept up in the excitement, so much so that they mistakenly give away Blythe's cell phone as a prize.

A frivolous quarrel blows up and halts communication among the pets, leading Blythe to fear she may lose the capacity to talk to them.

Minka paints in a new style, but she's displeased with it and doesn't want her name attached, so Blythe obliges and winds up taking credit for the art.

Blythe plans to enlist her famous cousin to help boost the sales of Sweet Delights. Sunil asks for the pets help to convince his parents that he is a doctor.

An anxious moose bellows, so Blythe and the pets try to soothe it in order not to disturb Mrs. Twombly's singing quartet reunion.

A red panda comes to the camp and intrigues Penny Ling. Meanwhile, Blythe composes a short story about her parents as teenagers.

Blythe books an Internet celebrity for a grand-opening appearance at the Littlest Pet Street, but she and the gang must pick the star up at her island home.

The gang attempt to leave Felina Meow's island. Meanwhile, Mrs. Twombly is overwhelmed as she carries out grand-opening preparations for the Littlest Pet Street.