Brain Box was a live, interactive quiz show, showing in Northern Ireland and the Republic of Ireland on UTV, and in Scotland on STV, airing every night, beginning after midnight.

The quiz show launched on UTV in Northern Ireland and the Republic of Ireland on Monday 3 August 2009, and on STV in Scotland just over a year later, on Thursday 19 August 2010. The show began airing on TV3 in the Republic of Ireland on 9 September 2010, just 7 months after the axing of the controversial Play TV. The channel ceased transmission of the programme just a week later, without explanation.

Brain Box is a commercial presentation, by NetPlay TV – in association with Challenge Jackpot. Although broadcast only in Scotland and Ireland, the show was actually produced at Teddington Studios.