Schillinger has a disappointing visit with his "hero", Mayor Loewen. Glynn has to face up to the truth when Oz loses its first prisoner to toxic poisoning. Down in solitary, Officer Brass gets some quality one-on-one time with Morales. Cyril undergoes a round of unusual therapy, and Said gets more than he bargained for in leading the Muslims into a new business venture.

Everyone has a different opinion of new inmate Idzik; Alvarez receives shocking news; Redding's attempts at reform continue; Murphy makes a confession to Glynn; Morales'(David Zayas) medical suspicions are confirmed; and Beecher's devotion to Keller leads him into a perilous position.

Idzik faces his enemies; the intrigues behind the Loewen case get more complicated; changes are made in the hospital; the Muslims run into business trouble; Rebadow and Stella get closer; and the inmates rally to support the O'Reilys.

Three new inmates arrive, one of whom is close to the O'Reilys; Busmalis and Rebadow prove to be "true Romeos"; the Keller-Beecher-Schillinger triangle gets more pointed; and an awards banquet ends in a fateful discovery.