Sister Pete's anger is roused and forces her to confession. Wangler and Adebisi register a complaint to the Warden. Yet another inmate meets with demise. Bellinger enlists McManus' help. Glynn and Hughes have an important conversation. Adebisi begins sowing seeds of discontent and a fight erupts in the gym resulting in a lockdown.

McManus calls a superficial truce between Redding and Morales. Basil finally sees his wife, but Hughes ends up spoiling their happiness. Meanwhile, Cyril's latest outburst proves to be the last straw.

McManus finds he is unable to turn his back on White. Beecher tells the parents of the young girl he killed that he's up for parole. Howell tries to blackmail O'Reily so she can get to Cyril, but he throws her for a loop--and then O'Reily is thrown himself by a family secret.

Guerra kills Alvarez's new follower and the guilt surrounding it forces Alvarez to make a confession to Mukada. Alvarez, Hill and Penders sign up for a seeing-eye dog-training program. Dr. Nathan attacks a patient while having a flashback of her rape. Cyril shanks and kills Li Chien, which gets Cyril sent to solitary and Ryan sent to the cage. During an interaction session Beecher attacks Schillinger after Schillinger denies ever raping him. Redding asks Glynn for control of the kitchen. Hill's grief over his dead mother and divorce from his wife send him back to drugs happily supplied by Poet. Beecher's new podmate is the son of a prominent family Beecher knew well. Because of that, Beecher decides to protect him from the Aryans at all costs.

Said and Arif go to Warden Glynn about Lalar's murder. Angry and full of rage, Said then confronts White about passing drugs. Unsatisfied with White's response, Said beats White severely, which gets Said thrown in the hole. Chucky Pancamo's condition worsens. On orders from Schillinger, Winthrop gets into a fight with Guenzel. Schillinger goes to with a deal, he'll let Beecher work for him delivering mail to Keller if Beecher has Guenzel transferred to Gen Pop so Schillinger can have him. Keller discovers the feds have compelling evidence linking him to one of the past murders. Meanwhile, Howell makes her move on Keller, Rebadow's ship comes in...for someone else and Hill becomes gravely ill.

The unexpected arrival of Mayor Wilson Loewen at Oz spurs an ironic turn involving Schillinger and Beecher. Meanwhile, Dr. Nathan discovers why solitary inmates are getting sick; a new business plan within Oz inspires Redding; Schibetta looks to puts a curse on the O'Reily family; and some Death Row prisoners get a bang out of a magazine photo shoot.

Schillinger has a disappointing visit with his "hero", Mayor Loewen. Glynn has to face up to the truth when Oz loses its first prisoner to toxic poisoning. Down in solitary, Officer Brass gets some quality one-on-one time with Morales. Cyril undergoes a round of unusual therapy, and Said gets more than he bargained for in leading the Muslims into a new business venture.

Idzik faces his enemies; the intrigues behind the Loewen case get more complicated; changes are made in the hospital; the Muslims run into business trouble; Rebadow and Stella get closer; and the inmates rally to support the O'Reilys.