A team of U.S. marshals led by Annie Frost searches for dangerous fugitive Mason Boyle.

U.S. Marshals Annie Frost and Daisy Ogbaa team up to catch small-town fugitives Karen Nelson and Ivy Collins, a duo who use their feminine wiles to lure innocent victims into participating in bank heists. Annie and Daisy become closer while working to break the fugitives' twisted , co-dependent bond before they continue down a self-destructive road.

A drug distributor's wife kills the lead witness in her husband's case in an effort to keep her family together; Marco remembers his dark days with the narcotics division; Jimmy is forced to make a decision about his relationship.