The murder of two tourists leads Five-0 to a man suffering from multiple personality disorder, where one of them becomes violent and another is a child. McGarrett is accompanied on the case by a stress management consultant, whom Danny and the others have hired to help him manage his health.

Thanksgiving brings Grover’s parents and brother Percy Jr. to Oahu for a visit tainted by sibling rivalry, and Five-0 investigates a thief who is crushed to death by an empty safe.

Five-0 teams up with a DEA agent to search for a killer whose plane crashed in the jungle with $10 million worth of heroin on board. Also, Grover is thrilled when his niece Siobhan comes to try out for the University of Hawaii basketball team.