Five-0 must work with rogue MI-6 agent Harry Langford to find a terrorist planning to cause nuclear reactors across Europe to meltdown. Also, McGarrett and Danny ask retired FBI profiler Alicia Brown to help them find their serial killer vigilante.

Alicia awakens in her bed to find another body with a chess piece in his mouth beside her. The team hunts for a cartel boss whose soldiers are gunning for a member of the team. Kono reconnects with Rosie.

Five-0 must find McGarrett and Alicia when they are kidnapped by the serial killer they’ve been hunting,

McGarrett and Five-0 once again become entangled in the twisted mind games of serial killer Dr. Madison Gray when she stumbles into HPD covered in blood that matches Alicia Brown's, and claims amnesia.

At Halloween, Five-0 must investigate a string of murders that mirror stories from well-known Hawaiian folklore. Also, Grover is called to visit a man hours away from execution who may hold the key to a case that has plagued Grover for years.

The murder of two tourists leads Five-0 to a man suffering from multiple personality disorder, where one of them becomes violent and another is a child. McGarrett is accompanied on the case by a stress management consultant, whom Danny and the others have hired to help him manage his health.