Five-0 is set up when a bad tip leads them to an abandoned building that is rigged to explode with McGarrett and Danny trapped inside.

Five-0 must find a kidnapped patient infected with a contagious and lethal strain of bird flu which the culprits intend to weaponize.

While Five-0 investigates the murder of a bounty hunter after he apprehended a fugitive hiding out in Hawaii, Rachel reveals a long-held secret to Danny that has serious ramifications. Also, as Kono’s wedding nears, Chin voices his concerns to McGarrett that Adam is still working with the Yakuza.

Five-0 investigates when a wealthy recluse is found dead in a remote field with nearly one million dollars in counterfeit bills. Also, Adam is kidnapped by the Yakuza and forced to torture one of Gabriel’s men.

When a conspiracy theorist with compelling evidence that JFK's cabinet ordered his assassination is murdered, Five-0 investigate's one of history's most notorious unsolved mysteries.

Danny protects a coma patient showing signs of waking who was the key witness from his last HPD case before he met Steve and joined Five-0.

When investigating a deserted yacht adrift at sea, McGarrett, Danny, Tani and Junior are exposed to a deadly bioweapon and the rest of Five-0 have only eight hours to find an antidote.

Adam's mission to take down organized crime on the Island goes sideways when deadly chlorine gas he was using to bait a big fish falls into the wrong hands. Also, Adam begins to doubt Jessie's allegiance.

Five-0 investigate the murder of a window washer and find that the victim is actually a renowned street artist who may have a politically motivated bounty on his head. Also, Grover and Adam look into the murder of a gambler, and Junior helps his father when they are reminded of his sister’s death.