Steve McGarrett is summoned home to the island of Honolulu to bury his father after he is murdered by a madman. Governor Jameson wants Steve to head up a new elite police unit and she will give him full authority to get the job done. Initially he turns down the job, but when he meets the man in charge of the unit, he changes his mind.

When Danny's ex-partner is found dead at a Hawaiian luau the Five-0 team's investigation leads them to some dirty cops and a powerful cocaine cartel.

It's Christmas in Hawaii, but instead of celebrating, Five-0 is negotiating a hostage situation when the man who killed McGarrett's father resurfaces. The murderer, Victor Hesse, threatens to detonate an explosive that he's strapped to Chin Ho's chest.

With the invaluable information that was shared by Agent Jenna Kaye, Five-0 is closer than ever to capturing Wo Fat. Their mission takes an abrupt turn, however, when Danny is exposed to a lethal neurological agent that presents an even greater threat: bio-terrorism on the island.

Danny and McGarrett investigate the murder of an Oahu University professor whose body is found decomposing in a tub of acid and his boss, his teaching assistant and a student who he busted for cheating are all viable suspects.

Chin Ho is kidnapped and wakes to find himself trapped in Halawa prison disguised as an inmate. With no time to waste, the team must bypass the rules to save Chon Ho’s life.

When McGarrett is kidnapped by Wo Fat, he experiences what would have happened to the team if they had taken a very different path, on the 100th episode.

Five-0 races to Mexico where Chin puts his life on the line after his niece Sara is kidnapped.

MacGarrett and Danny finally track down the missing uranium, which has been used to build a bomb located in the middle of the jungle. Now, they must carefully extract the unstable explosive through treacherous terrain before it detonates.