The FIVE-0’s investigation into the murder of a wealthy restaurant owner causes McGarrett to take part in a charity MMA fight to the finish. Meanwhile, NCIS Agent Kensi Blye lends her expertise to McGarrett and Lt. Commander White when they ask her to examine a video of McGarrett’s father.

When Danno and his family are targeted by a vengeful dirty cop from Danno's past, the team steps in to help.

Just as McGarrett finally gets his hands on his arch nemesis Wo Fat in a special ops raid, he’s blindsided when he finds that the Japanese Yakuza is hot on their trail and wants them both dead.

While the team investigates the murder of a young computer hacker, McGarrett tries to stage a long-needed reunion between his mother and his sister.

The team is directed to investigate when a prostitute is murdered in a Congressman's home, who is nowhere to be found. Danny has his own drama as the custody hearing regarding Grace goes to court.

When McGarrett is kidnapped by Wo Fat, he experiences what would have happened to the team if they had taken a very different path, on the 100th episode.