The mysterious Mrs. X tasks the sexy - and dangerous - Sophie to cause Jim and George to fall under her spell and make them do whatever she wants them to - which could place Jim's marriage in jeopardy. Meanwhile, Stephanie must decide whether or not to inject a patient with the trilsettum serum and risk turning him into a super in order to retain Dr. King's trust, and Daphne's boyfriend, Chris, begins to have suspicions about the Powell family's abilities.

The Powell's lives are in danger when a super-villain with animal like powers is tasked by Mrs. X to eliminate the family.